75000 - Document - Document and Entity Information
link:presentationLink
link:calculationLink
link:definitionLink
75010 - Statement - CONSOLIDATED BALANCE SHEETS
link:presentationLink
link:calculationLink
link:definitionLink
75020 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
75030 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS
link:presentationLink
link:calculationLink
link:definitionLink
75040 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS
link:presentationLink
link:calculationLink
link:definitionLink
75050 - Statement - CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' EQUITY
link:presentationLink
link:calculationLink
link:definitionLink
75060 - Statement - CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' EQUITY (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
995457 - Disclosure - Cybersecurity Risk Management, Strategy and Governance
link:presentationLink
link:calculationLink
link:definitionLink
995467 - Disclosure - Nature of Business and Significant Accounting Policies
link:presentationLink
link:calculationLink
link:definitionLink
995477 - Disclosure - Discontinued Operations
link:presentationLink
link:calculationLink
link:definitionLink
995487 - Disclosure - XOMA Transaction
link:presentationLink
link:calculationLink
link:definitionLink
995497 - Disclosure - Collaboration Agreements
link:presentationLink
link:calculationLink
link:definitionLink
995507 - Disclosure - Fair Value Measurements
link:presentationLink
link:calculationLink
link:definitionLink
995517 - Disclosure - Cash and Cash Equivalents
link:presentationLink
link:calculationLink
link:definitionLink
995527 - Disclosure - Property and Equipment, Net
link:presentationLink
link:calculationLink
link:definitionLink
995537 - Disclosure - Debt
link:presentationLink
link:calculationLink
link:definitionLink
995547 - Disclosure - Liability Related to Sale of Royalties
link:presentationLink
link:calculationLink
link:definitionLink
995557 - Disclosure - Leases and Contingencies
link:presentationLink
link:calculationLink
link:definitionLink
995567 - Disclosure - Prepaid Expenses, Other Current Assets, Accrued Expenses, and Other Current Liabilities
link:presentationLink
link:calculationLink
link:definitionLink
995577 - Disclosure - Reverse Stock Split
link:presentationLink
link:calculationLink
link:definitionLink
995587 - Disclosure - Net Income (Loss) per Share
link:presentationLink
link:calculationLink
link:definitionLink
995597 - Disclosure - Equity
link:presentationLink
link:calculationLink
link:definitionLink
995607 - Disclosure - 401(K) Savings Plan
link:presentationLink
link:calculationLink
link:definitionLink
995617 - Disclosure - Income Taxes
link:presentationLink
link:calculationLink
link:definitionLink
995627 - Disclosure - Segment Information
link:presentationLink
link:calculationLink
link:definitionLink
995637 - Disclosure - Subsequent Events
link:presentationLink
link:calculationLink
link:definitionLink
995647 - Disclosure - Nature of Business and Significant Accounting Policies (Policies)
link:presentationLink
link:calculationLink
link:definitionLink
995657 - Disclosure - Nature of Business and Significant Accounting Policies (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995667 - Disclosure - Discontinued Operations (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995677 - Disclosure - Cash and Cash Equivalents (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995687 - Disclosure - Property and Equipment, Net (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995697 - Disclosure - Prepaid Expenses, Other Current Assets, Accrued Expenses, and Other Current Liabilities (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995707 - Disclosure - Debt (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995717 - Disclosure - Liability Related to Sale of Royalties (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995727 - Disclosure - Leases and Contingencies (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995737 - Disclosure - Net Loss per Share (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995747 - Disclosure - Equity (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995757 - Disclosure - Income Taxes (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995767 - Disclosure - Segment Information (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995777 - Disclosure - Nature of Business and Significant Accounting Policies - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995787 - Disclosure - Nature of Business and Significant Accounting Policies - Schedule of Estimated Useful Lives of Property and Equipment (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995797 - Disclosure - Discontinued Operations - Summary of Reconciliation of Carrying Amounts of Assets and Liabilities and Income (Loss) from Discontinued Operation (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995807 - Disclosure - Discontinued Operations - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995817 - Disclosure - XOMA Transaction - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995827 - Disclosure - Collaboration Agreements - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995837 - Disclosure - Fair Value Measurements - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995847 - Disclosure - Cash and Cash Equivalents - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995857 - Disclosure - Cash and Cash Equivalents - Schedule of Cash and Cash Equivalents (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995867 - Disclosure - Cash and Cash Equivalents - Schedule of Cash and Cash Equivalents (Details) 2
link:presentationLink
link:calculationLink
link:definitionLink
995877 - Disclosure - Property and Equipment, Net - Summary of Property and Equipment (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995887 - Disclosure - Property and Equipment, Net - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995897 - Disclosure - Debt - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995907 - Disclosure - Debt - Schedule of Future Principal, Interest, and Other Related Fee Payments in Connection with the Credit Agreement (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995917 - Disclosure - Liability Related to Sale of Royalties - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995927 - Disclosure - Liability Related to Sale of Royalties - Schedule of Changes in the Liability Related to the Sale of Royalties (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995937 - Disclosure - Leases and Contingencies - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995947 - Disclosure - Leases and Contingencies - Components of Lease Expense (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995957 - Disclosure - Leases and Contingencies - Summary of Right of Use Assets Acquired Under Operating Leases (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995967 - Disclosure - Leases and Contingencies - Summary of Future Minimum Lease Payments (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995977 - Disclosure - Leases and Contingencies - Summary of Future Minimum Lease Payments (Details) 2
link:presentationLink
link:calculationLink
link:definitionLink
995987 - Disclosure - Prepaid Expenses, Other Current Assets, Accrued Expenses, and Other Current Liabilities - Summary of Prepaid Expenses and Other Current Assets (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995997 - Disclosure - Prepaid Expenses, Other Current Assets, Accrued Expenses, and Other Current Liabilities - Summary of Accrued Expenses and Other Current Liabilities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996007 - Disclosure - Reverse Stock Split - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996017 - Disclosure - Net Loss per Share - Computation of Basic and Diluted Net Loss per Share (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996027 - Disclosure - Net Loss per Share - Summary of Potentially Dilutive Shares Excluded from Calculation of Net Loss Per Share (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996037 - Disclosure - Equity - 2023 Common Warrants - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996047 - Disclosure - Equity - 2024 Common Warrants - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996057 - Disclosure - Equity - 2025 Common Warrants - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996067 - Disclosure - Equity - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996077 - Disclosure - Equity - Additional Information (Details1)
link:presentationLink
link:calculationLink
link:definitionLink
996087 - Disclosure - Equity - Summary of Common Warrant Activity (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996097 - Disclosure - Equity - Assumptions used in Estimating the Incremental Fair Value of the Exchanged Common Warrants under Black-scholes Valuation Model (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996107 - Disclosure - Equity - Summary of Fair Value of Common Warrants Prior to and Immediately After Exercise Price Adjustment, were Estimated Using Black-Scholes Option-Pricing Model Assumptions (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996117 - Disclosure - Equity - Summary of Stock-based Compensation Expense Includes Amortization of Stock Options and Restricted Stock Units Granted (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996127 - Disclosure - Equity - Standby Equity Purchase Agreement - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996137 - Disclosure - Equity - At The Market Offering Agreement - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996147 - Disclosure - Equity - Summary of Stock Option Activity (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996157 - Disclosure - Equity - Summary of Restricted Stock Activity (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996167 - Disclosure - 401(K) Savings Plan - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996177 - Disclosure - Income Taxes - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996187 - Disclosure - Income Taxes - Schedule of Loss from Continuing Operations Before Income Taxes (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996197 - Disclosure - Income Taxes - Schedule of Tax Effects of Temporary Differences Give Rise to Significant Portions of Deferred Tax Assets and Deferred Tax Liabilities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996207 - Disclosure - Income Taxes - Schedule of Reconciliation of Federal Statutory Income Tax Rate to Effective Income Tax from Continuing Operations (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996217 - Disclosure - Income Taxes - Schedule of Reconciliation of Federal Statutory Income Tax Rate to Effective Income Tax from Continuing Operations (Details) 2
link:presentationLink
link:calculationLink
link:definitionLink
996227 - Disclosure - Segment Information - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996237 - Disclosure - Segment Information - Summary of Significant Expense Categories (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996247 - Disclosure - Segment Information - Summary of Significant Asset Categories (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996257 - Disclosure - Subsequent Events - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Weighted Average Fair Value per Unit, Vested
Income (Loss) from Continuing Operations before Income Taxes, Foreign
International
Net (loss) income from continuing operations
Income (Loss) from Continuing Operations, Net of Tax, Including Portion Attributable to Noncontrolling Interest
Net loss from continuing operations
Net loss
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Preferred Stock, Shares Issued
Preferred stock, shares issued
Defined Benefit Plan, Plan Assets, Contributions by Employer
Matching contributions made by employer
Gross proceeds from warrant exercises
Gross proceeds from warrant exercises
Gross proceeds from warrant exercises.
Existing Warrants [Member]
Existing warrants.
Existing Warrants
Tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Amount [Abstract]
Increase decrease in operating lease right of use assets.
Increase Decrease In Operating Lease Right Of Use Assets
Operating lease right-of-use asset
Plan Name [Axis]
Plan Name
Equity [Abstract]
Entity Current Reporting Status
Entity Current Reporting Status
Proceeds from Warrant Exercises
Proceeds from exercise of common warrants, net of issuance costs
Operating Expenses [Abstract]
Operating expenses:
Operating Expenses [Abstract]
Fair Value, Inputs, Level 2 [Member]
Level Two
Deferred Tax Assets, Net of Valuation Allowance
Deferred tax assets, net of valuation
Class Of Warrant Or Right Expected Average Life Of Warrants
Class of warrant or right expected average life of warrants.
Expected average life
Common Stock, Shares Authorized
Common stock, shares authorized
Product and Service [Axis]
Fair Value by Liability Class [Domain]
Fair Value by Liability Class
Document Fiscal Period Focus
Document Fiscal Period Focus
Share based compensation arrangement by share based payment award equity instrument other than options expected to vest number.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instrument Other Than Options Expected To Vest Number
Number of Units, Outstanding and expected to vest
Entity Shell Company
Entity Shell Company
Other accruals
Other Accrued Liabilities, Current
Segment Reporting, Policy [Policy Text Block]
Segment Reporting
Total cash and cash equivalents
Cash and Cash Equivalent
Cash and cash equivalents
Shares of common stock issued for cash consideration
Shares Of Common Stock Issued For Cash Consideration
Shares of common stock issued for cash consideration.
Liability Related to Sale of Royalties
Liability related to sale of future royalties disclosure.
Liability Related To Sale Of Future Royalties Disclosure [Text Block]
Property Plant And Equipment Useful Life Table [Text Block]
Property plant and equipment useful life.
Schedule of Estimated Useful Lives of Property and Equipment
Credit Agreement
Credit agreement member.
Credit Agreement [Member]
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Common stock issued
Common Stock, Shares, Issued
Common stock, shares issued
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Statement [Table]
Statement [Table]
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Total operating leases
Broadridge Corporate Issuer Solutions.
Broadridge Corporate Issuer Solutions [Member]
Broadridge Corporate Issuer Solutions
Share-Based Payment Arrangement, Disclosure [Abstract]
Weighted-Average Remaining Term, Exercised
Class Of Warrant Or Right Exercised Weighted Average Remaining Contractual Term
Class of warrant or right exercised weighted average remaining contractual term.
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average grant date fair value per share of options granted
2025 Common Warrants
Two Thousand Twenty Five Common Warrants [Member]
Two thousand twenty five common warrants.
Long-Term Debt, Maturities, Repayments of Principal in Rolling Year Two
2024
Deferred payment
Disposal group including discontinued operations deferred revenue.
Disposal Group Including Discontinued Operations Deferred Revenue
Deferred payment from Medexus
Statement [Line Items]
Statement [Line Items]
Business Combination [Domain]
Business Acquisition, Acquiree
Weighted-Average Remaining Term, Exercisable
Class Of Warrant Or Right Exercisable Weighted Average Remaining Contractual Term
Class of warrant or right exercisable weighted average remaining contractual term.
Warrant [Member]
Warrants
Common Warrants
Entity Filer Category
Entity Filer Category
Reclassification, Comparability Adjustment [Policy Text Block]
Reclassification
Number of Shares, Issued
Class Of Warrant Or Right Issued
Class of warrant or right issued.
Reverse Stock Split [Abstract]
Reverse stock split.
Selling, General and Administrative Expenses, Policy [Policy Text Block]
General and Administrative Expenses
Alligator Bioscience [Member]
Alligator Bioscience.
Liabilities and Equity
Total liabilities and stockholders' equity
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted-Average Exercise Price, Exercisable
Share based compensation arrangement by share based payment award equity instruments other than options, expected to vest, weighted average grant date fair value.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Expected To Vest Weighted Average Grant Date Fair Value
Weighted Average Fair Value per Unit, Outstanding and expected to vest
Weighted Average Fair Value per Unit, Outstanding and expected to vest
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Increase in valuation allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Decrease in valuation allowance
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Federal tax at statutory rates
Common stock price per share
Shares Issued, Price Per Share
Offering price
Subsequent Event [Line Items]
Cybersecurity Risk Management Third Party Engaged [Flag]
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Percentage of cost related to research and development
Research And Development Cost Percentage
Research and development cost percentage.
Effective Income Tax Rate Reconciliation, Percent
Total income tax benefit
Stock Option
Income Tax Jurisdiction [Axis]
Income Tax Authority
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Restricted Cash
Percentage of Gross Sales Price Shares Sold
Percentage of gross sales price shares sold.
Percentage of gross sales price shares sold
Additional Paid in Capital, Common Stock
Additional paid-in capital
Deferred Tax Assets, Property, Plant and Equipment
Fixed Assets
Cash equivalents maturity period.
Cash Equivalents Maturity Period
Cash equivalents, maturity period
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Dividend declared of preferred share purchase right.
Dividend Declared Of Preferred Share Purchase Right
Preferred share purchase right
Measurement Input, Risk Free Interest Rate [Member]
Risk-free Interest Rate
Additional amount to be received upon exercise of warrants
Additional Amount To Be Received Upon Exercise Of Warrants
Additional amount to be received upon exercise of warrants.
Schedule of Cash and Cash Equivalents
Schedule of Cash and Cash Equivalents [Table Text Block]
Dividend attributable to down round feature of warrants
Warrant, Down Round Feature, Decrease in Net Income to Common Shareholder, Amount
Increase in net loss attributable to common equity due to deemed dividend
Dividend attributable to down round feature of warrants
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Number of Shares, Granted
Cybersecurity Risk Management, Strategy, and Governance [Table]
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Computation of Basic and Diluted Net Loss per Share
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount [Abstract]
Nontaxable or nondeductible items
Liability [Member]
Liability
Earnings Per Share, Basic
Basic net loss per share
Basic net loss per share
Retirement Benefits [Text Block]
401(K) Savings Plan
Fair Value Of Existing Common Warrants Immediately Before
Fair value of existing common warrants immediately before.
Fair value of existing common warrants immediately before
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of Shares, Outstanding, Ending balance
Number of Shares, Outstanding, Beginning balance
Number of shares outstanding under share-based payment arrangement
Debt Extinguishment
Debt, Policy [Policy Text Block]
Debt Issuance Costs
Liabilities, Current
Total current liabilities
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Domestic Tax Jurisdiction [Member]
Federal
Accounting Standard Update 2017 05 [Member]
Accounting standard update 2017 05.
ASC 610-20
Lessee operating lease liability payments due year four and beyond.
Lessee Operating Lease Liability Payments Due Year Four and Beyond
2029 and beyond
Accounting Standards Update [Axis]
Equity, Attributable to Parent [Abstract]
Stockholders' equity:
Entity Small Business
Entity Small Business
Percentage of entitlement to receive Canadian approval milestone payment.
Percentage of entitlement to receive Canadian Approval Milestone Payment
Percentage of entitlement to receive Canadian approval milestone payment
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock-based compensation
Software and hardware.
Software And Hardware [Member]
Software and Hardware
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Amount
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Amount, Total
Effects of cross-border tax laws
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Number of share options forfeited
Number of Shares, Forfeited
Number of Shares, Forfeited
Effective Income Tax Rate Reconciliation Changes in Unrecognized Tax Benefits
Effective income tax rate reconciliation changes in unrecognized tax benefits.
Changes in unrecognized tax benefits
Proceeds from Issuance Initial Public Offering
Sale of Stock, Price Per Share
Average price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Aggregate Intrinsic Value, Exercised
Warrants and Rights Outstanding, Measurement Input
Warrants measurement input
Schedule of earnings per share basic and diluted.
Schedule Of Earnings Per Share Basic And Diluted [Table]
Schedule Of Earnings Per Share Basic And Diluted [Table]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Defined Contribution Plan [Table]
Defined Contribution Plan [Table]
Deferred tax assets capitalized research expenditures.
Deferred Tax Assets Capitalized Research Expenditures
Capitalized research expenditures
Leases [Abstract]
Series A
Common Class A [Member]
Stock Issued During the Period Shares Warrant Modification
Stock issued during the period shares warrant modification.
Warrant modification - incremental fair value (in shares)
Lessee, Lease, Description [Line Items]
Lessee Lease Description [Line Items]
Amendment Flag
Amendment Flag
Product and Service [Domain]
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Federal tax at statutory rates
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Number of common stock to be issued up conversion of warrants
Warrants to purchase common stock
Finance Lease, Interest Expense
Interest on lease liabilities
Financing lease remaining expense obligation
Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block]
Nature of Business and Significant Accounting Policies
Lincoln Park Member
Lincoln Park [Member]
Lincoln Park
Liabilities and Equity [Abstract]
LIABILITIES AND STOCKHOLDERS' EQUITY
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash used in operating activities
Net cash used in operating activities
Net cash used in operating activities
Operating lease liability
Increase (Decrease) in Operating Lease Liability
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Common Stock [Member]
Common Stock
Cybersecurity Risk Role of Management [Text Block]
Tax Credit Carryforward, Amount
Tax credit carryforwards
Schedule of Changes in the Liability Related to the Sale of Royalties
Schedule of changes in the liability related to the sale of future royalties.
Schedule Of Changes In Liability Related To Sale Of Future Royalties Table [Text Block]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted-Average Exercise Price, Granted
Lessee, Operating Lease, Liability, to be Paid, Year Three
2028
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less: Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Entity Address, Address Line One
Entity Address, Address Line One
Deferred Tax Liabilities, Gross
Deferred tax liability
Deferred Tax Liabilities, Gross, Total
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Assumptions used in Valuing the Stock Options Granted under Black-Scholes Valuation Model
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Earnings Per Share [Abstract]
Basic and diluted net loss per share:
Income Tax, Policy [Policy Text Block]
Income Taxes
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Supplemental Cash Flow Information [Abstract]
Supplemental Cash Flow Information
Operating lease property number of units.
Operating Lease Property Number Of Lab Equipment
Operating lease number of piece for lab equipment
Royalty Revenue
Royalty Revenue Policy Policy [Text Block]
Royalty revenue.
Operating Lease, Right-of-Use Asset
Operating lease right-of-use asset
Operating lease right-of-use asset
Deferred Tax Assets, Gross
Deferred tax assets, gross
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Registered Direct Offering [Member]
Registered Direct Offering.
Registered Direct Offering
Deferred tax assets gain related to sale of future royalties.
Deferred Tax Assets Gain Related To Sale Of Future Royalties
Gain related to sale of future royalties
Class of Warrant or Right [Axis]
Document Type
Document Type
Warrant Inducement Agreement
Warrant Inducement Agreement [Member]
Warrant inducement agreement.
Income Taxes Paid, Net
Cash income taxes paid
Income Taxes Paid, Net, Total
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Entity Central Index Key
Entity Central Index Key
Liability related to sale of royalties, beginning balance
Liability related to sale of royalties, ending balance
Liability Related To Sale Of Royalties
Liability related to sale of royalties.
Line of Credit Facility [Table]
Line Of Credit Facility [Table]
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Increase (decrease) in cash and cash equivalents
Subsequent Event Type [Domain]
Subsequent Event Type
Kamada [Member]
Kamada [Member]
Kamada.
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Anti-dilutive shares excluded from calculation of diluted net loss per share
Disposal Group Classification [Domain]
Disposal Group Classification
Common stock par value
Common Stock, Par or Stated Value Per Share
Common stock, par value
Money Market Funds, at Carrying Value
Money market funds
Accounting Standards Update [Domain]
Accrued clinical, research and development costs
Accrued clinical, research and development costs.
Proceeds from Issuance of Warrants
Proceeds
Warrant inducement, net of issuance cost
Operating Lease, Right-of-Use Asset, Periodic Reduction
Non-cash lease expense
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Term, Outstanding
Defined Contribution Plan Disclosure [Line Items]
Defined Contribution Plan Disclosure [Line Items]
Payment in lieu of fractional shares
Adjustments to Additional Paid in Capital, Stock Split
Weighted-Average Exercise Price, Issued
Class Of Warrant Or Right Issued Weighted Average Exercise Price
Class of warrant or right issued weighted average exercise price.
Exercise Price of 17,982.00 [Member]
Exercise price of 17,982.00.
Exercise Price of 17,982.00
Document Financial Statement Error Correction [Flag]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Common stock issued upon exercise of stock options
Number of Shares, Exercised
Debt Disclosure [Abstract]
Summary of Fair Value of Common Warrants Prior to and Immediately After Exercise Price Adjustment, were Estimated Using Black-Scholes Option-Pricing Model Assumptions
Fair Value Measurement and Measurement Inputs, Recurring and Nonrecurring [Text Block]
Current Fiscal Year End Date
Current Fiscal Year End Date
Schedule of Long-Term Debt Instruments [Table]
Debt Instrument [Table]
Non Rule 10b51 Arr Modified [Flag]
Non Rule 10b51 Arr Modified [Flag]
Non-Rule 10b5-1 Arrangement Modified
Entity Address, State or Province
Entity Address, State or Province
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Number of Units, Outstanding, Ending balance
Number of Units, Outstanding
Adjustments to Additional Paid in Capital, Shares witheld in Lieu of Cash payment
Adjustments to additional paid in capital, shares witheld in lieu of cash payment.
Less: Shares W/H in Lieu of Cash Pmt
Less: Shares W/H in Lieu of Cash Pmt
Debt Issuance Costs, Gross
Transaction costs
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Research and Development Expense, Policy [Policy Text Block]
Research and Development expense
Disposal Groups, Including Discontinued Operations, Disclosure [Text Block]
Discontinued Operations
Percentage of entitlement to receive deferred payments.
Percentage of entitlement to receive deferred payments
Percentage of entitlement to receive deferred payments
Class of Warrant or Right [Domain]
Percentage of commitment fee
Percentage of Commitment Fee
Percentage of commitment fee.
Payments for Royalties
RUXIENCE royalties paid by Pfizer to HCR
One time payment of royalties
State and local income taxes, net of federal income tax effect
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Stock-based Compensation Expense Includes Amortization of Stock Options and Restricted Stock Units Granted
Other
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount
Proceeds from Royalties Received
Proceeds from royalties received
Proceeds from sale of royalties, net of transaction costs
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Tax Effects of Temporary Differences Give Rise to Significant Portions of Deferred Tax Assets and Deferred Tax Liabilities
Preclinical Program General Research And Discovery [Member]
Preclinical program general research and discovery.
Preclinical Program, General Research And Discovery
Collaborative Arrangement Disclosure [Text Block]
Collaboration Agreements
Weighted-Average Remaining Term, Issued
Class Of Warrant Or Right Issued Weighted Average Remaining Contractual Term
Class of warrant or right issued weighted average remaining contractual term.
Subsequent Event [Member]
Subsequent Event
Property, Plant and Equipment [Abstract]
Fair Value Measurement Inputs and Valuation Techniques [Table]
Measurement Input, Expected Term [Member]
Expected Average Life
Expected Average Life of Warrants
Expected dividend yield
Class Of Warrant Or Right Expected Dividend Yield
Class of warrant or right expected dividend yield.
Share based compensation arrangement by share based payment award maximum number of returning shares from old plan to be added to shares reserve.
Share Based Compensation Arrangement By Share Based Payment Award Maximum Number Of Returning Shares From Old Plan To Be Added To Shares Reserve
Maximum number of returning shares from old plan to be add to shares reserve
Antidilutive Securities [Axis]
Antidilutive Securities
Weighted-Average Exercise Price, Exercisable
Class Of Warrant Or Right Exercisable Weighted Average Exercise Price
Class of warrant or right exercisable weighted average exercise price.
Prepaid Expenses, Other Current Assets, Accrued Expenses, and Other Current Liabilities [Abstract]
Prepaid expenses, other current assets, accrued expenses, and other current liabilities.
Basis of Presentation and Significant Accounting Policies [Text Block]
Basis of Presentation
Proceeds From Issuance Of Warrants Share
Proceeds from issuance of warrants share.
Warrant inducement, net of issuance cost ( in shares)
State and Local Jurisdiction [Member]
State
Related Party Transaction [Axis]
Related Party Transaction
Dividend attributable to down round feature of warrants
Dividend Attributable To Down Round Feature Of Warrants
Dividend Attributable To Down Round Feature Of Warrants
Warrant modification - incremental value
Warrant modification incremental value
Warrant modification incremental value.
Lessee, Operating Lease, Option to Extend
Operating lease renewal option description
Preferred Stock, Value, Issued
Preferred stock: $0.001 par value; 15,000,000 shares authorized, zero shares issued or outstanding
Disposal Groups, Including Discontinued Operations [Table Text Block]
Summary of Reconciliation of Carrying Amounts of Assets and Liabilities and Income (Loss) from Discontinued Operation
Payment of amount outstanding.
Payment Of Amount Outstanding
Payment Of Amount Outstanding
Minimum [Member]
Minimum
Minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted Average Fair Value per Unit, Granted
Assets, Current [Abstract]
Current assets:
Series B
Common Class B [Member]
Fair Value, Inputs, Level 3 [Member]
Level Three
Segment Reporting [Abstract]
Gain on contingent consideration
Discontinued Operating Gain on Contingent Consideration.
Discontinued Operating Gain On Contingent Consideration
Tax Period [Domain]
Tax Period
Liabilities, Current [Abstract]
Current liabilities:
IXINITY.
I X I N I T Y [Member]
IXINITY
Share based compensation arrangement by share based payment award forfeiture rate.
Share Based Compensation Arrangement By Share Based Payment Award Forfeiture Rate
Estimated forfeiture rate
Related Party Transactions [Abstract]
Fractional Shares
Fractional Shares [Member]
Fractional shares.
Shares, Outstanding
Balance (in shares)
Balance (in shares)
Operating Loss Carryforwards
Net operating loss carryforwards
Lessee, Operating Lease, Renewal Term
Operating lease renewal option term
Placement Agent and Legal Fees
Placement agent and legal fees.
Placement agent and legal fees
Lessee, Leases [Policy Text Block]
Leases
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Weighted Average Fair Value per Unit, Outstanding Ending Balance
Weighted Average Fair Value per Unit, Outstanding Beginning Balance
Series A and Series B Common Warrants
Series A and Series B common warrants [Member]
Series A and Series B common warrants.
Equity
Shareholders' Equity and Share-Based Payments [Text Block]
Tax credit carryforward, expiration year.
Tax Credit Carryforward Expiration Year
Tax credits, begin to expiration year
General and Administrative Expense [Member]
General and Administrative
Operating Lease, Liability
Operating lease liability
Total
Operating Lease, Liability, Total
Auditor Firm ID
Auditor Firm ID
Office space lease.
Office Space Lease [Member]
Office Space Lease
Stockholders' Equity, Reverse Stock Split
Reverse Stock Split, outstanding common stock
Forecast [Member]
Scenario Forecast
Common Stock Shares Issuance Approval Threshold Percentage
Common stock shares issuance approval threshold percentage.
Percentage of outstanding shares approved for potential issuance
Weighted-Average Exercise Price, Exercised with shares held in abeyance
Class Of Warrant Or Right Exercised With Shares Held In Abeyance Weighted Average Exercise Price
Class of warrant or right exercised with shares held in abeyance weighted average exercise price.
Restricted Cash, Current
Restricted cash
Current restricted cash
Fair Value Measurement Inputs and Valuation Techniques [Abstract]
Number of Shares, Exercised with shares held in abeyance
Class Of Warrant Or Right Exercised With Shares Held In Abeyance
Class of warrant or right exercised with shares held in abeyance.
Two lease renewal option.
Two Lease Renewal Option [Member]
Renewal Option Two
Lessee, Lease, Description [Table]
Lessee Lease Description [Table]
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Change in valuation allowances
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net loss
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Weighted Average Number of Shares Outstanding, Basic
Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Basic shares used in calculation
Proceeds from exercise of common warrants shares
Proceeds from exercise of common warrants shares.
Proceeds from exercise of common warrants (in shares)
Restrictions on Cash and Cash Equivalents [Table]
Schedule Of Restricted Cash And Cash Equivalents [Table]
Aptevo BioTherapeutics
Aptevo BioTherapeutics [Member]
Aptevo BioTherapeutics [Member]
Aptevo BioTherapeutics.
Scenario [Axis]
Scenario
Lessee finance lease remaining term of contract.
Lessee Finance Lease Remaining Term Of Contract
Financing lease remaining term
First Standby Equity Purchase Agreement [Member]
First standby equity purchase agreement member.
First Standby Equity Purchase Agreement
Aggregate intrinsic value of options exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate Intrinsic Value, Exercisable
Effective Income Tax Rate Reconciliation, Tax Expense (Benefit), Share-Based Payment Arrangement, Percent
Stock-based compensation
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Reconciliation of Federal Statutory Income Tax Rate to Effective Income Tax from Continuing Operations
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Stock Issued During Period, Shares, Reverse Stock Splits
Payment in lieu of fractional shares (in shares)
Payment in lieu of fractional shares (in shares)
Closing payments
Closing payments received
Closing payments received.
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Subsequent Events [Text Block]
Subsequent Events
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Tax credits/Orphan Drug tax credits
Tax credits/Orphan Drug tax credits
Debt outstanding
Long-Term Debt
Total
XOMA Transaction
Related Party Transactions Disclosure [Text Block]
Cash
Cash
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total
Variable Rate [Domain]
Variable Rate
Changes in valuation allowances
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Equity, Attributable to Parent
Balance
Balance
Total stockholders' equity
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Lessee, Operating Lease, Existence of Option to Extend [true false]
Operating lease option to extend
Beneficial ownership exceeding percentage of outstanding common stock
Beneficial ownership exceeding percentage of outstanding common stock.
Statement of Stockholders' Equity [Abstract]
Increase Decrease in Long Term Operating Leases Liability
Increase decrease in long term operating leases liability.
Long-term operating lease liability, net of current portion
Mipletamig [Member]
Mipletamig.
Mipletamig
Second Standby Equity Purchase Agreement [Member]
Second Standby Equity Purchase Agreement member.
Second Standby Equity Purchase Agreement
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Expiration amount of operating loss carryforwards
Expiration Amount Of Operating Loss Carryforwards
Amount of operating loss due to expire
Leaseholds and Leasehold Improvements [Member]
Leasehold Improvements
Stock issued during period shares restricted stock award net of forfeitures and stock options exercised.
Stock Issued During Period Shares Restricted Stock Award Net of Forfeitures and Stock Options Exercised
Common stock issued upon vesting of restricted stock units and exercised stock options (in shares)
Entity Address, Address Line Two
Entity Address, Address Line Two
Fair Value Disclosures [Text Block]
Fair Value Measurements
Gross proceeds
Proceeds Of Warrants Issued During Period Gross
Proceeds of warrants issued during period gross.
Earliest Tax Year
Earliest Tax Year [Member]
Equity distribution agreement.
Equity Distribution Agreement [Member]
Equity Distribution Agreement
Class of warrant or right, expired
Class of warrant or right, expired.
Number of Shares, Expired
Payment interest purchase agreement.
Payment Interest Purchase Agreement [Member]
Payment Interest Purchase Agreement
Risk-free interest rate
Class Of Warrant Or Right Risk Free Interest Rate
Class of warrant or right risk free interest rate.
Summary of right of use assets acquired under operating leases.
Summary Of Right Of Use Assets Acquired Under Operating Leases Table [Text Block]
Summary of Right of Use Assets Acquired Under Operating Leases
Summary of Accrued Expenses and Other Current Liabilities
Schedule of Accrued Liabilities [Table Text Block]
Debt Instrument, Name
Debt Instrument, Name [Domain]
Other current assets
Other Assets, Current
Accrued expenses and other current liabilities
Accrued Liabilities and Other Liabilities
Accrued expenses and other current liabilities
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Plan Name [Domain]
Plan Name
Payment of royalty revenue
Payment of royalty revenue, percentage
Payment Of Royalty Revenue Percentage
Payment of royalty revenue, percentage.
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Entity [Domain]
Entity
Credit Facility [Axis]
Credit Facility
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price
Weighted-Average Exercise Price, vest and expected to vest
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Number of Shares, Outstanding, Ending Balance
Number of Shares, Outstanding, Beginning Balance
Class of Warrant or Right, Outstanding
Warrants outstanding
Outstanding warrants issued
Tax Period [Axis]
Tax Period
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Other adjustments
Series A Common Warrants
Series A Common Warrant [Member]
Series A common warrant.
Liability related to sale of future royalties.
Liability Related To Sale Of Future Royalties
Liability related to sale of future royalties, beginning balance
Liability related to sale of royalties, ending balance
2023 Common Warrants
Two Thousand Twenty Three Common Warrants [Member]
2023 Common Warrants.
Rule 10b51 Arr Modified [Flag]
Rule 10b51 arr modified flag.
Rule 10b5-1 Arrangement Modified
Exercise Price of 3,096.00 [Member]
Exercise price of 3,096.00.
Exercise Price of 3,096.00
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment
Disposal Group Name [Domain]
Entity Address, City or Town
Entity Address, City or Town
Reduction in research and development expense.
Reduction In Research And Development Expense
Research and development expense
Weighted-Average Exercise Price, Outstanding, Ending Balance
Weighted-Average Exercise Price, Outstanding, Beginning Balance
Class Of Warrant Or Right Outstanding Weighted Average Exercise Price
Class of warrant or right outstanding weighted average exercise price.
Security Exchange Name
Security Exchange Name
Credit Facility [Domain]
Credit Facility
Operating lease termination option written notice period.
Operating Lease Termination Option Written Notice Period
Operating lease termination option written notice period
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Other adjustments
Property, Plant and Equipment, Gross
Property and equipment, gross
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Schedule of Financing Receivables, Minimum Payments [Table Text Block]
Schedule of Future Principal, Interest, and Other Related Fee Payments in Connection with the Credit Agreement
Counterparty Name [Axis]
Counterparty Name
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Loss from continuing operations before benefit from income taxes
Prepaid Expenses, Other Current Assets, Accrued Expenses, and Other Current Liabilities
Prepaid Expenses, Other Current Assets, Accrued Expenses, and Other Current Liabilities [Text Block]
The entire disclosure for prepaid expenses, other current assets, accrued expenses, and other current liabilities.
Measurement Input Type [Domain]
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Share based compensation arrangement by share based payment award options granted intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Options Granted Intrinsic Value
Aggregate Intrinsic Value, Granted
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Foreign tax effects
Series A Junior Participating Preferred Stock.
Series A Junior Participating Preferred Stock [Member]
Series A Junior Participating Preferred Stock
Deferred Tax Assets, Goodwill and Intangible Assets
Intangible assets
Statistical Measurement [Domain]
Statistical Measurement
Stock offering aggregate price
Stock Offering Aggregate Price
Stock offering aggregate price.
Class of Warrant or Right, Exercise Price of Warrants or Rights
Warrants exercise price, per share
Assets, Current
Total current assets
Share-Based Payment Arrangement, Expense
Stock-based compensation expense
Document Period End Date
Document Period End Date
Title and Position [Axis]
Title of Individual
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Number of Shares, Exercisable
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Statement of Financial Position [Abstract]
Restricted Stock Units (RSUs) [Member]
Unvested RSUs
RSUs
Number of warrants issued.
Number Of Warrants Issued
Number of warrants issued
Gain related to sale of non-financial asset
Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal
Gain related to sale of non-financial asset
Class of Stock [Axis]
Class of Stock
Deferred Tax Liabilities, Net
Net deferred tax liabilities
Net deferred tax assets
Lessee operating lease unamortized real estate taxes interest rate.
Lessee Operating Lease Unamortized Real Estate Taxes Interest Rate
Operating lease termination option unamortized real estate taxes interest rate
Current Income Tax Expense (Benefit)
Income tax expense (benefit)
Current Income Tax Expense (Benefit), Total
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Warrants expiration date
Warrants and Rights Outstanding, Maturity Date
Basic and Diluted Net Income (Loss) per Share [Abstract]
Basic and diluted net income (loss) per share.
Basic and diluted net (loss) income per share:
Basic and diluted net loss per share
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Percent
Effect of changes in tax lax laws or rates enacted in the current period/Change in tax attributes
Liabilities
Total liabilities
Lessee, Operating Lease, Discount Rate
Operating lease discounted incremental borrowing rate
Sale of royalties liability disclosure abstract.
Sale Of Royalties Liability Disclosure [Abstract]
Summary Of Significant Asset Categories [Table Text Block]
Summary of significant asset categories.
Summary of Significant Asset Categories
Measurement Input, Exercise Price [Member]
Expected Dividend Yield
Liability related to sale of future royalties non current.
Liability Related To Sale Of Future Royalties Non Current
Liability related to sale of royalties, non-current
Proceeds from sale of investments
Proceeds from Sale of Investments.
Proceeds From Sale Of Investments
Dividends
Dividends, Total
Deemed dividend
Foreign tax effects
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Amount
Lessee, Operating Lease, Liability, to be Paid, Year Two
2027
Restricted Cash and Cash Equivalent Item [Line Items]
Restricted Cash And Cash Equivalents Items [Line Items]
Disposal Groups, Including Discontinued Operations [Table]
Income Statement Balance Sheet And Additional Disclosures By Disposal Groups Including Discontinued Operations [Table]
ALG.APV-527 [Member]
ALG.APV-527.
ALGAPV-527
Variable Rate [Axis]
Variable Rate
Weighted Average Number of Shares Outstanding, Diluted
Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Diluted shares used in calculation
Securities Act File Number
Entity File Number
Less: Shares W/H in Lieu of Cash Pmt (in shares)
Shares witheld in lieu of cash payment
Shares witheld in lieu of cash payment.
Less: Shares W/H in Lieu of Cash Pmt (in shares)
Non-employee directors.
Non Employee Directors [Member]
Non-employee Directors
Cover [Abstract]
Measurement Input Type [Axis]
Increase (Decrease) in Accounts Payable and Accrued Liabilities
Increase (Decrease) in Accounts Payable and Accrued Liabilities, Total
Accounts payable, accrued compensation, accrued expenses and other current liabilities, and short-term operating lease
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Number of Units, Forfeited
Cash and Cash Equivalents
Cash and Cash Equivalents Disclosure [Text Block]
Non-cash warrant modification costs
Non Cash Warrant Modification Costs
Non cash warrant modification costs.
Two thousand eighteen stock incentive plan.
Two Thousand Eighteen Stock Incentive Plan [Member]
2018 Stock Incentive Plan
Scenario [Domain]
Scenario
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Stock authorized for issuance under Stock Plan
Number of Operating Segments
Number of operating segments
Sale of Stock [Domain]
Segment Reporting Disclosure [Text Block]
Segment Information
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
General and administrative
Operating lease property number of copiers.
Operating Lease Property Number Of Copiers
Operating lease number of copiers
Subsequent Event [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Number of shares issued under share-based payment arrangement
Liability related to sale of royalties disclosure.
Liability Related To Sale Of Royalties Disclosure [Text Block]
Liability Related to Sale of Royalties
Deferred Tax Assets, Other
Other deferred tax assets
HCR
HCR [member].
H C R [Member]
Warrant modification - incremental fair value
Warrant modification - incremental value
Adjustments to Additional Paid in Capital, Warrant Issued
Milestone payment
Milestone payments.
Milestone Payment
Effect of changes in tax lax laws or rates enacted in the current period
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount
Property, Plant and Equipment, Useful Life
Estimated useful lives
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Adopted Accounting Pronouncements
Accounting Pronouncements Pending Adoption
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent
Other
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Stock plan vesting period
Issuance costs
Common Stock Issuance Costs
Common stock issuance costs.
Income (Loss) from Continuing Operations before Income Taxes, Domestic
US
Depreciation
Depreciation expense
Depreciation, Total
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized compensation expense
Nasdaq Capital Market.
Nasdaq Capital Market [Member]
Nasdaq Capital Market
Share based compensation arrangement by share based payment award options forfeitures in period intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period Intrinsic Value
Aggregate Intrinsic Value, Forfeited
Common stock outstanding
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Operating Lease, Liability, Current
Current portion of operating lease liabilities
Operating lease liability, current portion
Sharebased compensation arrangement by sharebased payment award options expected to vest weighted average period.
Sharebased Compensation Arrangement By Sharebased Payment Award Options Expected To Vest Weighted Average Period
Options expected to vest, weighted average period
Depreciation, Depletion and Amortization
Depreciation and amortization
Depreciation, Depletion and Amortization, Total
Cybersecurity Risk Management Processes Integrated [Flag]
Document Transition Report
Document Transition Report
Research and Development Expense
Research and development
Research and Development Expense, Total
Research and development
Lessee, Operating Leases [Text Block]
Leases and Contingencies
LIBOR [Member]
LIBOR.
Deferred Tax Assets, Operating Loss Carryforwards, State and Local
State losses carryforward
Statement of Cash Flows [Abstract]
Stock Issued During Period, Value, New Issues
Issuance of common stock, net
Issuance of common stock net of issuance cost
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
Purchase agreement.
Purchase Agreement [Member]
Purchase Agreement
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Share-based compensation
Share based compensation arrangement by share based payment award equity instrument other than options nonvested and expected to vest number.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instrument Other Than Options Nonvested And Expected To Vest Number
Number of Units, Outstanding and expected to vest
Reverse Stock Split
Reverse stock split.
Earnings Per Share [Text Block]
Net Loss per Share
Shares, Issued
Shares issued
Discontinued Operations and Disposal Groups [Abstract]
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Summary of RSU Activity
Lessee operating lease unamortized tenant improvement allowance interest rate.
Lessee Operating Lease Unamortized Tenant Improvement Allowance Interest Rate
Operating lease termination option unamortized tenant improvement allowance interest rate
Cybersecurity Risk Management Processes Integrated [Text Block]
Net loss
Net loss
Net loss
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Outstanding, Ending balance
Aggregate Intrinsic Value, Outstanding, Beginning balance
Derivative, Floor Interest Rate
Floor interest rate
Weighted-Average Remaining Term, Outstanding
Class Of Warrant Or Right Outstanding Weighted Average Remaining Contractual Term
Class of warrant or right outstanding weighted average remaining contractual term.
Operating Lease, Cost
Operating lease cost
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Line of Credit Facility [Line Items]
Line Of Credit Facility [Line Items]
For operating leases
Operating Lease, Payments
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Aggregate Intrinsic Value, Vested and expected to vest
Assets [Abstract]
ASSETS
Assets [Abstract]
Non cash interest expense.
Non Cash Interest Expense
Non-cash interest expense
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other current assets
Repayments of Debt
Repayment of debt
Document Fiscal Year Focus
Document Fiscal Year Focus
Income Tax Reconciliation Changes in Unrecognized Tax Benefits
Income tax reconciliation changes in unrecognized tax benefits.
Changes in unrecognized tax benefits
Federal and State
Federal And State [Member]
Federal and state.
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Investing Activities
Retirement Benefits [Abstract]
Accounts Payable, Current
Accounts Payable, Current, Total
Accounts payable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value
Total fair value of stock option vested
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Schedule of Loss from Continuing Operations Before Income Taxes
Research and Development Expense [Member]
Research and Development
Initial operating lease term date.
Initial Operating Lease Term Date
Initial operating lease term date
Defined Contribution Plan, Employer Matching Contribution, Percent of Match
Employer matching contribution, qualified deferral percentage
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block]
Summary of Prepaid Expenses and Other Current Assets
April 4 2025 Registered Direct Offering [Member]
April 4 2025 registered direct offering.
April 4, 2025 Registered Direct Offering
Fair Value Measurement, Policy [Policy Text Block]
Fair Value of Financial Instruments
Lease liabilities
Deferred tax assets lease liabilities.
Deferred Tax Assets Lease Liabilities
Milestone payment received net of transaction costs.
Milestone Payment Received Net Of Transaction Costs
Proceeds from milestone payments, net of transaction costs
Payments in lieu of fractional shares
Payments in lieu of fractional shares
Payments In Lieu Of Fractional Shares
Payments in lieu of fractional shares.
Fair Value Disclosures [Abstract]
ResearchAndDevelopmentExpenseSharedCostIncurredUnderCollaborationAgreement
Research And Development Expense Shared Cost Incurred Under CollaborationAgreement.
Effective Income Tax Rate Reconciliation, Tax Credit, Amount
Effective Income Tax Rate Reconciliation, Tax Credit, Amount, Total
Tax credits/Orphan Drug tax credits
Orphan Drug tax credits
Lessee, Operating Lease, Liability, to be Paid, Year One
2026
Additional post-closing payment.
Additional post-closing payment
Additional post-closing payment
Sale of Stock, Consideration Received on Transaction
Net proceeds
Net Income (Loss) Available to Common Stockholders, Basic
Net loss attributable to common stockholders
Net loss attributable to common stockholders
Number of Shares, Exercisable
Class Of Warrant Or Right Exercisable
Class of warrant or right exercisable
At The Market Offering
At The Market Offering [Member]
At The Market Offering.
At-The-Market Offering
Debt Instrument [Axis]
Debt Instrument
Assets, Fair Value Disclosure
Fair value assets
Assets, Fair Value Disclosure, Total
Sale of Stock [Axis]
Other segment items
Other Segment Items
Other segment items.
Hyperimmune Business
Hyperimmune Business [Member]
Hyperimmune business.
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash from investing activities
Finance lease number of equipment.
Finance Lease Number Of Equipment
Financing lease number of equipment
Title of 12(b) Security
Title of 12(b) Security
Schedule of Segment Reporting Information, by Segment [Table]
Share-based compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Share Repurchase Program, Remaining Authorized, Amount
Remaining availability under SEPA
Remaining availability
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted-Average Exercise Price, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Weighted Average Fair Value per Unit, Forfeited
Additional milestone payment.
Additional Milestone Payment
Additional milestone payment
Income Tax Disclosure [Text Block]
Income Taxes
Number of operating lease renewal options.
Number Of Operating Lease Renewal Options
Number of operating lease renewal option
Other long-term liabilities
Other Liabilities, Noncurrent
Fair Value Of Newly Issued Warrants
Fair value of newly issued warrants.
Fair value of newly issued warrants
Legal Entity [Axis]
Legal Entity
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Property, Plant and Equipment [Table Text Block]
Summary of Property and Equipment
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted-Average Exercise Price, Outstanding, Ending balance
Weighted-Average Exercise Price, Outstanding, Beginning balance
Income Tax Disclosure [Abstract]
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Assumptions used in Estimating the Incremental Fair Value of the Exchanged Common Warrants under Black-scholes Valuation Model
Assumptions Of Incremental Fair Value Of Warrants [Table Text Block]
Assumptions of incremental fair value of warrants.
Assumptions used in Valuing the Stock Options Granted under Black-Scholes Valuation Model
Unrecognized Tax Benefits
Uncertain income tax positions
Unrecognized Tax Benefits, Beginning Balance
Unrecognized Tax Benefits, Ending Balance
Additional Paid-in Capital [Member]
Additional Paid-In Capital
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Statement of Income Location, Balance [Axis]
Income Statement Location
Trading Symbol
Trading Symbol
Weighted-Average Exercise Price, Exercised
Class Of Warrant Or Right Exercised Weighted Average Exercise Price
Class of warrant or right exercised weighted average exercise price.
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment, Net
Related Party Transaction [Table]
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Permanent differences
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
Subsequent Event Type [Axis]
Subsequent Event Type
Employee-related Liabilities, Current
Employee-related Liabilities, Current, Total
Accrued compensation and benefits
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Financing Activities
Accrued Expenses and Other Current Liabilities
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Lessee, Operating Lease, Liability, to be Paid
Total Future minimum lease payments
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: imputed interest
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Schedule of earnings per share basic and diluted.
Schedule Of Earnings Per Share Basic And Diluted [Line Items]
Schedule Of Earnings Per Share Basic And Diluted [Line Items]
Equity Components [Axis]
Equity Components
Proceeds from sale of investments used.
Proceeds From Sale Of Investments Used
Proceeds from sale of investments used
Equity Component [Domain]
Equity Component
Share portion entitled to purchase by rights.
Share Portion Entitled To Purchase By Rights1
Share portion entitled to purchase by rights
Fair Value Of Inducement Transaction Common Warrants
Fair value of inducement transaction common warrants.
Fair value of December 2024 inducement transaction common warrants
Document Annual Report
Document Annual Report
Business Combination [Axis]
Business Acquisition
Public Offering
IPO [Member]
Machinery and Equipment [Member]
Copier Leases
Measurement Input, Option Volatility [Member]
Expected Volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Stock plan termination period
Nature Of Business [Line Items]
Nature Of Business [Line Items]
Nature Of Business [Line Items]
Share based compensation arrangement by share based payment award options expected to vest weighted average remaining vesting period.
Share Based Compensation Arrangement By Share Based Payment Award Options Expected To Vest Weighted Average Remaining Vesting Period
Options expected to vest, weighted average remaining vesting term
Deferred Tax Assets, Operating Loss Carryforwards, Domestic
Federal losses carryforward
Maximum [Member]
Maximum
Maximum
Liabilities, Fair Value Disclosure
Fair value liabilities
Liabilities, Fair Value Disclosure, Total
Statistical Measurement [Axis]
Statistical Measurement
Tabular disclosure of future minimum payments required for operating leases.
Schedule Of Future Minimum Payments For Operating Leases Table [Text Block]
Summary of Future Minimum Lease Payments
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted-Average Exercise Price, Exercised
November Two Thousand Twenty Three Warrants [Member]
November two thousand twenty three warrants.
November 2023 Warrants
Prepaid Expense, Current
Prepaid Expense, Current, Total
Prepaid clinical expenses
Common Stock, Value, Issued
Common stock: $0.001 par value; 500,000,000 shares authorized; 997,830 and 4,051 shares issued and outstanding at December 31, 2025 and December 31, 2024, respectively
Common stock value
Derivative, Fixed Interest Rate
Interest rate
Finance Lease, Principal Payments
Financing lease payments
Cash and Cash Equivalents [Abstract]
Gain from extinguishment of liability related to sale of royalties
Gain on extinguishment of liability related to sale of royalties.
Gain On Extinguishment Of Liability Related To Sale Of Royalties
Gain on extinguishment of liability related to sale of royalties
Gain from extinguishment of liability related to sale of royalties
Equipment [Member]
Lab Equipment Lease
Schedule of changes in the liability related to the sale of royalties.
Schedule Of Changes In Liability Related To Sale Of Royalties Table [Text Block]
Schedule of Changes in the Liability Related to the Sale of Royalties
Expected volatility
Class Of Warrant Or Right Expected Volatility Rate
Class of warrant or right expected volatility rate.
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Warrant Activity [Table Text Block]
Warrant activity.
Summary of Common Warrant Activity
Fair value of existing common warrants immediately after
Fair Value Of Existing Common Warrants Immediately After
Fair value of existing common warrants immediately after.
Tang [member].
Tang [Member]
Tang
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State and local income taxes, net of federal income tax effect
Series B Common Warrants
Series B Common Warrants [Member]
Series B Common Warrants.
Value of equity awards withheld for tax liability
Value Of Equity Awards Withheld For Tax Liability
Value of equity awards withheld for tax liability.
Other Nonoperating Income (Expense) [Abstract]
Other income:
Entity Public Float
Entity Public Float
Number of technology platforms.
Number Of Technology Platforms
Number of technology platforms
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
RUXIENCE
R U X I E N C E [Member]
R U X I E N C E
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Percent
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Percent, Total
Effects of cross-border tax laws
Related Party Transaction [Line Items]
Entity Registrant Name
Entity Registrant Name
Debt Disclosure [Text Block]
Debt
Percentage of entitlement to receive European approval milestone payment
Percentage of entitlement to receive European approval milestone payment
Percentage of entitlement to receive European approval milestone payment.
Percentage Of Beneficial Ownership.
Percentage Of Beneficial Ownership
Percentage of beneficial ownership
Entity Voluntary Filers
Entity Voluntary Filers
Number of Shares, Exercised
Class Of Warrant Or Right Exercised
Class of warrant or right exercised.
Common warrants exercised
Other Nonoperating Income (Expense)
Other Nonoperating Income (Expense), Total
Other income, net
ELOC [Member]
ELOC.
ELOC
Subsequent Events [Abstract]
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate [Member]
Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate
SOFR
Total income tax benefit
Income Tax Expense (Benefit)
Proceeds from issuance of common stock, pre-funded warrants exercise, and common warrants exercise, net of issuance costs
Costs from issuance of common stock
Gross proceeds
Weighted-Average Remaining Term, Exercised with shares held in abeyance
Class Of Warrant Or Right Exercised With Shares Held In Abeyance Weighted Average Remaining Contractual Term
Class of warrant or right exercised with shares held in abeyance weighted average remaining contractual term.
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Structuring Fee
Structuring fee.
Structuring fee
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentrations of Credit Risk
Liability Class [Axis]
Liability Class
Disposal Group Classification [Axis]
Disposal Group Classification
Seattle office lease including amendment.
Seattle Office Lease Including Amendment [Member]
Seattle Office Lease, Including Amendment
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Number of Units, Granted
Deferred Tax Assets, Tax Credit Carryforwards, Other
Other tax credits
Assets
Total assets
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Term, Exercisable
Income Statement [Abstract]
Income taxes.
Income Taxes [Line Items]
Income Taxes [Line Items]
Share-Based Payment Arrangement [Policy Text Block]
Stock-Based Compensation
Number of shares sold
Sale of Stock, Number of Shares Issued in Transaction
Issuance of common stock shares
Costs from issuance of common stock (in shares)
Issuance of common stock net of issuance cost (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Number of Units, Vested
Earnings Per Share, Diluted
Diluted net loss per share
Diluted net loss per share
December 2024 Warrants
December 2024 Warrants [Member]
December 2024 Warrants.
Class of warrant or right expired weighted average exercise price
Class of warrant or right expired weighted average exercise price.
Weighted-Average Exercise Price, Expired
Title and Position [Domain]
Title of Individual
Property, Plant, and Equipment, Useful Life, Term, Description [Extensible Enumeration]
City Area Code
City Area Code
Liability related to sale of royalties and other income (expense).
Liability Related To Sale Of Royalties And Other Income (Expense) Policy [Text Block]
Liability Related to Sale of Royalties and Other Income (Expense)
Auditor Name
Auditor Name
Mid Cap financial [Member]
Mid Cap Financial [Member]
Mid Cap Financial
Operating leases, excluding Seattle office lease.
Operating Leases Excluding Seattle Office Lease [Member]
Operating Leases, Excluding Seattle Office Lease
Income (Loss) from Discontinued Operations, Net of Tax, Including Portion Attributable to Noncontrolling Interest
Income from discontinued operations
Income from discontinued operations
Income from discontinued operations
Line of Credit Facility, Maximum Borrowing Capacity
Maximum borrowing capacity
December 2024 Warrant Inducement [Member]
December 2024 Warrant Inducement, member.
December 2024 Warrant Inducement
Counterparty Name [Domain]
Counterparty Name
Business Exit Costs
Exit fees
Variable Lease, Cost
Variable expenses
Prepaid Expenses and Other Current Assets [Policy Text Block]
Prepaid expenses and other current assets.
Prepaid Expenses and Other Current Assets
Share based compensation arrangement by share based payment award fair value assumptions expected volatility share price.
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Share Price
Expected volatility
Operating Lease, Weighted Average Remaining Lease Term
Weighted average remaining lease term for operating leases
Segment Reporting Information [Line Items]
Reverse stock split
Stockholders' Equity Note, Stock Split, Conversion Ratio
Stockholders' Equity Note, Stock Split, Conversion Ratio
Disposal Group Name [Axis]
Total issuance costs
Issuance of costs
Warrants Issuance Costs
Warrants issuance costs.
Letter of Credit [Member]
Letter of Credit
Operating loss carryforwards, expiration year.
Operating Loss Carryforwards Expiration Year
Operating losses, begin to expiration year
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash Equivalents
Property, Plant and Equipment, Net
Property and equipment, net
Total property and equipment, net
Nature Of Business [Table]
Nature Of Business [Table]
Nature Of Business [Table]
Number of Shares, Vest and expected to Vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number
Cash and cash equivalents at end of period
Cash and cash equivalents at beginning of period
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Operating Income (Loss)
Loss from operations
Retained Earnings [Member]
Accumulated Deficit
Pre-funded Warrants
Pre-funded Warrants [Member]
Pre-funded Warrants.
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation
Share-Based Payment Arrangement, Noncash Expense, Total
August Two Thousand Twenty Three Warrants [Member]
August wo thousand twenty three warrants.
August 2023 Warrant
Issuance costs
Payments of Stock Issuance Costs
Income taxes.
Income Taxes [Table]
Income Taxes [Table]
ROU assets
Deferred tax liability right of use assets.
Deferred Tax Liability Right Of Use Assets
Operating Lease, Weighted Average Discount Rate, Percent
Weighted discount rate for operating leases
Operating Lease, Liability, Noncurrent
Long term portion of operating lease liabilities
Operating lease liability, net of current portion
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Summary Of Significant Expense Categories [Table Text Block]
Summary of significant expense categories.
Summary of Significant Expense Categories
Lease, Cost [Table Text Block]
Components of Lease Expense
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent [Abstract]
Nontaxable or nondeductible items
Auditor Location
Auditor Location
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Income Statement Balance Sheet And Additional Disclosures By Disposal Groups Including Discontinued Operations [Line Items]
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Summary of Potentially Dilutive Shares Excluded from Calculation of Net Loss Per Share
Income Tax Jurisdiction [Domain]
Income Tax Authority
Entity Interactive Data Current
Entity Interactive Data Current
Statement of Income Location, Balance [Domain]
Income Statement Location
Derivative, Cap Interest Rate
Cap interest rate
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Operating Activities
Furniture and Fixtures [Member]
Furniture and Equipment
Liability related to sale of future royalties current.
Liability Related To Sale Of Future Royalties Current
Current portion of liability related to sale of royalties
Cash Equivalents, at Carrying Value
Cash equivalents
Cash Equivalents, at Carrying Value, Total
Line of Credit Facility, Current Borrowing Capacity
Line of credit facility, used borrowing capacity
Entity Tax Identification Number
Entity Tax Identification Number
Share Price
Minimum prevailing market price to direct purchase
Share price
Long-Term Debt, Maturities, Repayments of Principal in Next Rolling 12 Months
2023
Restricted stock units and options.
Restricted Stock Units And Options [Member]
RSUs and Options
Stock issued during period value restricted stock award net of forfeitures and stock options exercised.
Stock Issued During Period Value Restricted Stock Award Net of Forfeitures and Stock Options Exercised
Common stock issued upon vesting of restricted stock units and exercised stock options
Proceeds from Issuance or Sale of Equity
Proceeds from Issuance or Sale of Equity, Total
Net proceeds from sale of stock
Local Phone Number
Local Phone Number
Related Party Transaction [Domain]
Related Party Transaction
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Unrecognized compensation expense
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Shares used in calculation:
Auditor Opinion
Auditor Opinion [Text Block]
Accounting Policies [Abstract]
Royalty revenue
Revenues From Net Sales
Revenues from net sales.
Class of Stock [Domain]
Class of Stock
Standby Equity Purchase Agreement
Standby Equity Purchase Agreement [Member]
Standby equity purchase agreement.
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Number of shares available for grant
Accrued Professional Fees, Current
Accrued professional service costs
Maximum employee deferral rate
Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent
Proceeds from exercise of common warrants value
Proceeds from exercise of common warrants value.
Proceeds from exercise of common warrants
Proceeds from exercise of common warrants
Entity Emerging Growth Company
Entity Emerging Growth Company
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Term, Vested and expected to vest