Entity Central Index Key Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Filer Category Entity Filer Category Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company Entity Extended Transition Period Entity Ex Transition Period Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Sales rebates and discounts payable current. Statement Of Financial Position [Abstract] ASSETS Assets [Abstract] Current assets: Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Accounts receivable Accounts Receivable Net Current Inventories Inventory Net Prepaid expenses Prepaid Expense Current Other current assets Other Assets Current Total current assets Assets Current Restricted cash Restricted Cash Current Property and equipment, net Property Plant And Equipment Net Intangible assets, net Finite Lived Intangible Assets Net Operating lease right-of-use asset Operating Lease Right Of Use Asset Other assets Other Assets Noncurrent Total assets Assets LIABILITIES AND STOCKHOLDERS' EQUITY Liabilities And Stockholders Equity [Abstract] Current liabilities: Liabilities Current [Abstract] Accounts payable Accounts Payable Current Accrued compensation Employee Related Liabilities Current Sales rebates and discounts payable Sales Rebates And Discounts Payable Current Other short-term liabilities Other Liabilities Current Total current liabilities Liabilities Current Long-term debt, net Long Term Debt Noncurrent Operating lease liability, net of current portion Operating Lease Liability Noncurrent Other liabilities Other Liabilities Noncurrent Total liabilities Liabilities Stockholders' equity: Stockholders Equity [Abstract] Preferred stock: $0.001 par value; 15,000,000 shares authorized, zero shares issued or outstanding Preferred Stock Value Common stock: $0.001 par value; 500,000,000 shares authorized; 45,090,219 and 22,808,416 shares issued and outstanding at March 31, 2019 and December 31, 2018, respectively Common Stock Value Additional paid-in capital Additional Paid In Capital Common Stock Accumulated deficit Retained Earnings Accumulated Deficit Total stockholders' equity Stockholders Equity Total liabilities and stockholders' equity Liabilities And Stockholders Equity Preferred stock, par value Preferred Stock Par Or Stated Value Per Share Preferred stock, shares authorized Preferred Stock Shares Authorized Preferred stock, shares issued Preferred Stock Shares Issued Preferred stock, shares outstanding Preferred Stock Shares Outstanding Common stock, par value Common Stock Par Or Stated Value Per Share Common stock, shares authorized Common Stock Shares Authorized Common stock, shares issued Common Stock Shares Issued Common stock, shares outstanding Common Stock Shares Outstanding Income Statement [Abstract] Revenues: Revenues [Abstract] Product sales Revenue From Contract With Customer Excluding Assessed Tax Type of Revenue [Extensible List] Type Of Revenue Extensible List Costs and expenses: Costs And Expenses [Abstract] Cost of product sales Cost Of Goods And Services Sold Type of Cost, Good or Service [Extensible List] Type Of Cost Good Or Service Extensible List Research and development Research And Development Expense Selling, general and administrative Selling General And Administrative Expense Loss from operations Operating Income Loss Other expense, net Other Nonoperating Income Expense Net loss Net Income Loss Basic and diluted net loss per basic share Earnings Per Share Basic And Diluted Weighted-average shares used to compute per share calculations Weighted Average Number Of Share Outstanding Basic And Diluted Statement Of Income And Comprehensive Income [Abstract] Net loss Other comprehensive loss: Other Comprehensive Income Loss Net Of Tax Attributable To Parent [Abstract] Unrealized loss on available-for-sale investments, net Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax Total comprehensive loss Comprehensive Income Net Of Tax Non-cash interest expense and other. Increase decrease in operating lease right of use assets. Increase decrease in long term operating lease liability. Increase (decrease) in sales rebates and discounts. Proceeds from issuance of common stock, warrants, and pre-funded warrants, net. Proceeds from exercise of pre-funded warrants. Payment of tax liability for vested equity awards. Statement Of Cash Flows [Abstract] Operating Activities Net Cash Provided By Used In Operating Activities [Abstract] Net loss Profit Loss Adjustments to reconcile net loss to net cash used in operating activities: Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Stock-based compensation Share Based Compensation Depreciation and amortization Depreciation Depletion And Amortization Non-cash interest expense and other Non Cash Interest Expense And Other Changes in operating assets and liabilities: Increase Decrease In Operating Capital [Abstract] Accounts receivable Increase Decrease In Accounts Receivable Inventories Increase Decrease In Inventories Prepaid expenses and other current assets Increase Decrease In Prepaid Deferred Expense And Other Assets Operating lease right of use asset Increase Decrease In Operating Lease Right Of Use Assets Accounts payable, accrued compensation and other liabilities Increase Decrease In Accounts Payable And Accrued Liabilities Long-term operating lease liability Increase Decrease In Long Term Operating Lease Liability Sales rebates and discounts Increase Decrease In Sales Rebates And Discounts Net cash used in operating activities Net Cash Provided By Used In Operating Activities Investing Activities Net Cash Provided By Used In Investing Activities [Abstract] Proceeds from the maturity of investments Proceeds From Sale Maturity And Collections Of Investments Cash received from sale of Hyperimmune Business Proceeds From Divestiture Of Businesses Purchases of property and equipment Payments To Acquire Property Plant And Equipment Purchases of investments Payments To Acquire Investments Net cash (used in) provided by investing activities Net Cash Provided By Used In Investing Activities Financing Activities Net Cash Provided By Used In Financing Activities [Abstract] Proceeds from issuance of common stock, warrants, and pre-funded warrants, net Proceeds From Issuance Of Common Stock Warrants And Pre Funded Warrants Net Proceeds from exercise of common stock options Proceeds From Stock Options Exercised Proceeds from the exercise of pre-funded warrants Proceeds From Exercise Of Pre Funded Warrants Payment of tax liability for vested equity awards Payment Of Tax Liability For Vested Equity Awards Net cash provided by (used in) financing activities Net Cash Provided By Used In Financing Activities Increase in cash, cash equivalents, and restricted cash Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect Cash, cash equivalents, and restricted cash at beginning of period Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations Cash, cash equivalents, and restricted cash at end of period Stock issued during period shares common stock, pre-funded warrants and warrants, net. Stock issued during period value common stock, pre-funded warrants and warrants, net. Issuance of commitment shares of common stock, non-cash transaction. Issuance of commitment value of common stock, non-cash transaction. Statement Of Stockholders Equity [Abstract] Statement [Table] Statement [Table] Equity Components Statement Equity Components [Axis] Equity Component Equity Component [Domain] Common Stock Common Stock [Member] Additional Paid-In Capital Additional Paid In Capital [Member] Accumulated Deficit Retained Earnings [Member] Accumulated Other Comprehensive Loss Accumulated Other Comprehensive Income [Member] Statement [Line Items] Statement [Line Items] Balance Balance (in shares) Shares Outstanding Issuance of common stock, pre-funded warrants and warrants, net Stock Issued During Period Value Common Stock Pre Funded Warrants And Warrants Net Issuance of common stock, pre-funded warrants and warrants, net (in shares) Stock Issued During Period Shares Common Stock Pre Funded Warrants And Warrants Net Issuance of commitment shares of common stock, non-cash transaction Issuance Of Commitment Value Of Common Stock Non Cash Transaction Issuance of commitment shares of common stock, non-cash transaction (in shares) Issuance Of Commitment Shares Of Common Stock Non Cash Transaction Unrealized losses on available-for-sale investments Common stock issued upon exercise of stock options Stock Issued During Period Value Stock Options Exercised Common stock issued upon exercise of stock options (in shares) Stock Issued During Period Shares Stock Options Exercised Common stock issued upon vesting of restricted stock units Stock Issued During Period Value Restricted Stock Award Net Of Forfeitures Common stock issued upon vesting of restricted stock units (in shares) Stock Issued During Period Shares Restricted Stock Award Net Of Forfeitures Stock-based compensation Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value Net loss for the period Balance Balance (in shares) Accounting Policies [Abstract] Nature of Business and Significant Accounting Policies Organization Consolidation Basis Of Presentation Business Description And Accounting Policies [Text Block] Organization Consolidation And Presentation Of Financial Statements [Abstract] Collaboration Agreements Collaborative Arrangement Disclosure [Text Block] Fair Value Disclosures [Abstract] Fair Value Measurements Fair Value Disclosures [Text Block] Cash And Cash Equivalents [Abstract] Cash, Cash Equivalents, and Restricted Cash Cash And Cash Equivalents Disclosure [Text Block] Inventory Disclosure [Abstract] Inventories Inventory Disclosure [Text Block] Leases [Abstract] Leases Leases Of Lessee Disclosure [Text Block] Debt Disclosure [Abstract] Debt Debt Disclosure [Text Block] Earnings Per Share [Abstract] Net Loss Per Share Earnings Per Share [Text Block] Equity [Abstract] Equity Shareholders Equity And Share Based Payments [Text Block] Revenue From Contract With Customer [Abstract] Revenue Reserves Revenue From Contract With Customer [Text Block] Leases Lessee Leases Policy [Text Block] Other significant accounting policy. Other Significant Accounting Policies Other Significant Accounting Policy [Text Block] Recently adopted standards. Recently Adopted Standards Recently Adopted Standards Policy Policy [Text Block] Schedule of Cash, Cash Equivalents and Long-term Restricted Cash Schedule Of Cash And Cash Equivalents Table [Text Block] Schedule of Inventories Schedule Of Inventory Current Table [Text Block] Components of Lease Expense Lease Cost Table [Text Block] Summary of supplemental cash flows information related to leases. Summary of Supplemental Cash Flows Information Related to Leases Summary Of Supplemental Cash Flows Information Related To Leases Table [Text Block] Summary of Future Minimum Lease Payments Schedule Of Future Minimum Rental Payments For Operating Leases Table [Text Block] Summary of Potentially Dilutive Shares Excluded from Calculation of Net Loss Per Share Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block] Summary of Stock-based Compensation Expense Includes Amortization of Stock Options and Restricted Stock Units Granted Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block] Assumptions used in Valuing the Stock Options Granted under Black-Scholes Valuation Model Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block] Summary of Stock Option Activity Schedule Of Share Based Compensation Stock Options Activity Table [Text Block] Summary of RSU Activity Schedule Of Share Based Compensation Restricted Stock Units Award Activity Table [Text Block] Revenue of product revenue allowance and reserve categories. Summary of Product Revenue Allowance and Reserve Categories Revenue Of Product Revenue Allowance And Reserve Categories Table [Text Block] Number of revenue generating product. Nature Of Business [Line Items] Nature Of Business [Table] Nature Of Business [Table] Nature Of Business [Table] Range Range [Axis] Range Range [Member] Maximum Maximum [Member] Minimum Minimum [Member] Adjustments for New Accounting Pronouncements Adjustments For New Accounting Pronouncements [Axis] Type of Adoption Type Of Adoption [Member] ASU No. 2016-02 Accounting Standards Update201602 [Member] Nature Of Business [Line Items] Nature Of Business [Line Items] Number of revenue-generating product Number Of Revenue Generating Product Stock issued during period shares pre-funded warrants. Pre funded warrants exercise price. Number of common stock shares to be issued exercise of prefunded warrants. Additional proceeds to be received upon exercise of the warrants. Number of shares issued Stock Issued During Period Shares New Issues Number of common stock to be issued up conversion of warrants Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights Warrants exercise price, per share Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1 Issuance of pre-funded warrants Stock Issued During Period Shares Pre Funded Warrants Pre funded warrants exercise price, per share Pre Funded Warrants Exercise Price Number of common stock to be issued exercise of prefunded warrants Number Of Common Stock Shares To Be Issued Exercise Of Prefunded Warrants Proceeds from issuance of warrants Proceeds From Issuance Of Warrants Additional proceeds to be received upon exercise of the warrants Additional Proceeds To Be Received Upon Exercise Of Warrants Warrants outstanding, term Warrants And Rights Outstanding Term Operating lease liability Operating Lease Liability Decrease in deferred rent liability Increase Decrease In Prepaid Rent Reduction in research and development expense. Increase in research and development expense. Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table] Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table] Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] Reduction in research and development expense Reduction In Research And Development Expense Increase in research and development expense. Increase In Research And Development Expense Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Fair Value Hierarchy and NAV Fair Value By Fair Value Hierarchy Level [Axis] Fair Value Hierarchy and NAV Fair Value Measurements Fair Value Hierarchy [Domain] Level Two Fair Value Inputs Level2 [Member] Level Three Fair Value Inputs Level3 [Member] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] Money market funds Money Market Funds At Carrying Value Fair value assets Assets Fair Value Disclosure Cash equivalents maturity period. Schedule Of Restricted Cash And Cash Equivalents [Table] Schedule Of Restricted Cash And Cash Equivalents [Table] Financial Instrument Financial Instrument [Axis] Financial Instruments Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain] MidCap loan agreement. Covenant of MidCap Loan Agreement Mid Cap Loan Agreement [Member] Credit Facility Credit Facility [Axis] Credit Facility Credit Facility [Domain] Letter of Credit Letter Of Credit [Member] Restricted Cash And Cash Equivalents Items [Line Items] Restricted Cash And Cash Equivalents Items [Line Items] Cash equivalents, maturity period Cash Equivalents Maturity Period Long-term restricted cash Restricted Cash Noncurrent Cash Cash Cash equivalents Cash Equivalents At Carrying Value Restricted cash Total cash, cash equivalents, and restricted cash Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Inventory Adjustments [Abstract] Raw materials and supplies Inventory Raw Materials And Supplies Net Of Reserves Work-in-process Inventory Work In Process Net Of Reserves Finished goods Inventory Finished Goods Net Of Reserves Total inventories Operating lease agreement effective date. Operating lease termination option written notice period. Lessee Lease Description [Table] Lessee Lease Description [Table] Lease Arrangement, Type Lease Arrangement Type [Axis] Lease Arrangement, Type Lease Arrangement Type [Domain] Amended seven operating lease. Amendment Seven Operating lease Amended Seven Operating Lease [Member] Property, Plant and Equipment, Type Property Plant And Equipment By Type [Axis] Property, Plant and Equipment, Type Property Plant And Equipment Type [Domain] Office space lease. Office Space Lease Office Space Lease [Member] Amended eight operating lease. Amendment Eight Operating lease Amended Eight Operating Lease [Member] Type of Arrangement and Non-arrangement Transactions Type Of Arrangement [Axis] Arrangements and Non-arrangement Transactions Arrangements And Nonarrangement Transactions [Member] Two lease renewal option. Renewal Option Two Two Lease Renewal Option [Member] Lab Equipment Lease Equipment [Member] Copier Leases Machinery And Equipment [Member] Lessee Lease Description [Line Items] Lessee Lease Description [Line Items] Operating lease expiration amendment date Lease Expiration Date1 Operating lease effective amendment date Operating Lease Agreement Effective Date Operating lease square feet Area Of Land Operating lease renewal option description Lessee Operating Lease Option To Extend Operating lease renewal option to terminate description Lessee Operating Lease Option To Terminate Operating lease renewal option term Lessee Operating Lease Renewal Term Operating lease termination option written notice period Operating Lease Termination Option Written Notice Period Operating lease option to extend Lessee Operating Lease Existence Of Option To Extend Operating lease renewal option to terminate Lessee Operating Lease Existence Of Option To Terminate Lease expense Lease Cost Variable payments Variable Lease Cost Operating lease, discounted incremental borrowing rate Lessee Operating Lease Discount Rate Operating lease extended renewal option date. Operating lease extended renewal option date Operating Lease Extended Renewal Option Date Increase (decrease) operating lease right of use asset. Increase (decrease) operating lease liability. Operating lease right-of-use asset Increase Decrease Operating Lease Right Of Use Asset Operating lease liability Increase Decrease Operating Lease Liability Number of operating lease renewal options. Lessee operating lease unamortized tenant improvement allowance interest rate. Lessee operating lease unamortized real estate taxes interest rate. Number of operating lease renewal option Number Of Operating Lease Renewal Options Operating lease termination option unamortized tenant improvement allowance interest rate Lessee Operating Lease Unamortized Tenant Improvement Allowance Interest Rate Operating lease termination option unamortized real estate taxes interest rate Lessee Operating Lease Unamortized Real Estate Taxes Interest Rate Operating lease property number of units. Operating lease property number of copiers. Operating lease number of piece for lab equipment Operating Lease Property Number Of Lab Equipment Operating lease number of copiers Operating Lease Property Number Of Copiers Finance lease number of equipment. Lessee finance lease remaining term of contract. Financing lease number of equipment Finance Lease Number Of Equipment Financing lease remaining term Lessee Finance Lease Remaining Term Of Contract Financing lease remaining expense obligation Finance Lease Interest Expense Financing lease payments Finance Lease Principal Payments Operating lease cost Operating Lease Cost Finance lease cost: Finance Lease Cost [Abstract] Amortization of right-of-use assets Finance Lease Right Of Use Asset Amortization Interest on lease liabilities Total lease cost Operating leases, excluding Seattle office lease. Operating Leases, Excluding Seattle Office Lease Operating Leases Excluding Seattle Office Lease [Member] Seattle office lease including amendment. Seattle Office Lease, Including Amendment Seattle Office Lease Including Amendment [Member] Total operating leases Right Of Use Asset Obtained In Exchange For Operating Lease Liability For operating leases Operating Lease Payments 9 months ended December 31, 2019 Lessee Operating Lease Liability Payments Remainder Of Fiscal Year 12 months ended December 31, 2020 Lessee Operating Lease Liability Payments Due Year Two 12 months ended December 31, 2021 Lessee Operating Lease Liability Payments Due Year Three 12 months ended December 31, 2022 Lessee Operating Lease Liability Payments Due Year Four 12 months ended December 31, 2023 Lessee Operating Lease Liability Payments Due Year Five Total Future minimum lease payments Lessee Operating Lease Liability Payments Due Less: imputed interest Lessee Operating Lease Liability Undiscounted Excess Amount Total Long term portion of operating lease liabilities Weighted average remaining lease term for operating leases Operating Lease Weighted Average Remaining Lease Term1 Weighted discount rate for operating leases Operating Lease Weighted Average Discount Rate Percent Line Of Credit Facility [Table] Line Of Credit Facility [Table] Debt Instrument Debt Instrument [Axis] Debt Instrument, Name Debt Instrument Name [Domain] Credit facility first tranche. Credit Facility First Tranche Credit Facility First Tranche [Member] Credit facility second tranche. Credit Facility Second Tranche Credit Facility Second Tranche [Member] Amended credit agreement. Amended Credit Agreement Amended Credit Agreement [Member] Line Of Credit Facility [Line Items] Line Of Credit Facility [Line Items] Maximum borrowing capacity Line Of Credit Facility Maximum Borrowing Capacity Credit facility available and drawn Line Of Credit Prepayment of term loans. Termination amount of line of credit facility maximum borrowing capacity. Term loans extended amortization date based on achievement of revenue recognized. Revenue recognition of net commercial product date to be achieved. Principal repayments date deferred upon achievement of net commercial product revenues. Prepayment of term loans Prepayment Of Term Loans Terminated maximum borrowing capacity Termination Amount Of Line Of Credit Facility Maximum Borrowing Capacity Unrestricted cash balance Term loans extended amortization date based on net commercial product revenues recognized Term Loans Extended Amortization Date Based On Achievement Of Revenue Recognized Net commercial product revenue, date to be achieved Revenue Recognition Of Net Commercial Product Date To Be Achieved Net commercial product revenue required to be achieved on trailing twelve month basis Contract With Customer Liability Revenue Recognized Net commercial product revenue requirements to be maintained Revenue Performance Obligation Description Of Good Or Service Revenue Principal repayments date deferred upon achievement of net commercial product revenues Principal Repayments Date Deferred Upon Achievement Of Net Commercial Product Revenues Line of credit facility deferral date of first required payment. Line of credit, repayment begin date Line Of Credit Facility Date Of First Required Payment1 Line of credit, repayment deferral begin date Line Of Credit Facility Deferral Date Of First Required Payment Long-term restricted cash Credit agreement, maturity date Line Of Credit Facility Expiration Date1 Credit agreement reference rate for the variable rate Debt Instrument Description Of Variable Rate Basis Credit agreement basis spread on variable rate Debt Instrument Basis Spread On Variable Rate1 Schedule of earnings per share basic and diluted. Schedule of earnings per share basic and diluted. Schedule Of Earnings Per Share Basic And Diluted [Table] Schedule Of Earnings Per Share Basic And Diluted [Table] Antidilutive Securities Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis] Antidilutive Securities, Name Antidilutive Securities Name [Domain] Warrants Warrant [Member] Outstanding Options to Purchase Common Stock Employee Stock Option [Member] Unvested RSUs Restricted Stock Units R S U [Member] Schedule Of Earnings Per Share Basic And Diluted [Line Items] Schedule Of Earnings Per Share Basic And Diluted [Line Items] Anti-dilutive shares excluded from calculation of diluted net loss per share Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount Number of warrants issued. Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Vesting Vesting [Axis] Vesting Vesting [Domain] Tranche One Share Based Compensation Award Tranche One [Member] Equity distribution agreement. Equity Distribution Agreement Equity Distribution Agreement [Member] Plan Name Plan Name [Axis] Plan Name Plan Name [Domain] Converted equity awards incentive plan. Converted Equity Awards Incentive Plan Converted Equity Awards Incentive Plan [Member] Two thousand sixteen stock incentive plan. 2016 Stock Incentive Plan Two Thousand Sixteen Stock Incentive Plan [Member] Title of Individual Title Of Individual [Axis] Relationship to Entity Title Of Individual With Relationship To Entity [Domain] Non-employee directors. Non-employee Directors Non Employee Directors [Member] Award Type Award Type [Axis] Equity Award Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain] RSUs Minimum Two thousand eighteen stock incentive plan. 2018 Stock Incentive Plan Two Thousand Eighteen Stock Incentive Plan [Member] Stock Option Maximum Tranche Two Share Based Compensation Award Tranche Two [Member] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Shares issued price per share Shares Issued Price Per Share Number of warrants issued Number Of Warrants Issued Pre funded warrant issued price per share. Pre funded warrants and rights outstanding term. Pre funded warrant issued price, per share Pre Funded Warrant Issued Price Per Share Pre funded warrants outstanding, term Pre Funded Warrants And Rights Outstanding Term Proceeds upon exercise of stock options Common stock issued upon exercise of stock options Common stock issued upon vesting of restricted stock units Stock Issued During Period Shares Restricted Stock Award Gross Aggregate offering price. Aggregate offering price Aggregate Offering Price Issuance of common stock shares Stock authorized for issuance under Stock Plan Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Authorized Stock plan vesting period Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1 Stock plan termination period Sharebased Compensation Arrangement By Sharebased Payment Award Expiration Period Increase in number of authorized shares issuable. Increase of authorized shares issuable Increase In Number Of Authorized Shares Issuable Share based compensation arrangement by share based payment award maximum number of returning shares from old plan to be added to shares reserve. Maximum number of returning shares from old plan to be add to shares reserve Share Based Compensation Arrangement By Share Based Payment Award Maximum Number Of Returning Shares From Old Plan To Be Added To Shares Reserve Number of shares available for grant Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Income Statement Location Income Statement Location [Axis] Income Statement Location Income Statement Location [Domain] Research and Development Research And Development Expense [Member] Selling, General and Administrative Selling General And Administrative Expenses [Member] Stock-based compensation expense Allocated Share Based Compensation Expense Expected dividend yield Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate Expected volatility Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Risk-free interest rate Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Expected average life of options Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1 Share based compensation arrangement by share based payment award forfeiture rate. Estimated forfeiture rate Share Based Compensation Arrangement By Share Based Payment Award Forfeiture Rate Number of Shares, Outstanding, Beginning balance Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number Number of Shares, Granted Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross Number of Shares, Exercised Number of Shares, Forfeited Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period Number of Shares, Outstanding, Ending balance Number of Shares, Exercisable Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number Weighted-Average Exercise Price, Outstanding, Beginning balance Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Weighted-Average Exercise Price, Granted Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price Weighted-Average Exercise Price, Exercised Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price Weighted-Average Exercise Price, Forfeited Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price Weighted-Average Exercise Price, Outstanding, Ending balance Weighted-Average Exercise Price, Exercisable Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price Weighted-Average Remaining Term, Outstanding Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2 Weighted-Average Remaining Term, Exercisable Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1 Share based compensation arrangement by share based payment award options granted intrinsic value. Share based compensation arrangement by share based payment award options forfeitures in period intrinsic value. Aggregate Intrinsic Value, Outstanding, Beginning balance Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value Aggregate Intrinsic Value, Granted Share Based Compensation Arrangement By Share Based Payment Award Options Granted Intrinsic Value Aggregate Intrinsic Value, Exercised Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value Aggregate Intrinsic Value, Forfeited Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period Intrinsic Value Aggregate Intrinsic Value, Outstanding, Ending balance Aggregate Intrinsic Value, Exercisable Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1 Sharebased compensation arrangement by sharebased payment award options expected to vest weighted average period. Share based compensation arrangement by share based payment award options outstanding and exercisable weighted average remaining contractual term. Unrecognized compensation expense Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options Options expected to vest, weighted average period Sharebased Compensation Arrangement By Sharebased Payment Award Options Expected To Vest Weighted Average Period Options outstanding and exercisable weighted average remaining contractual life Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding And Exercisable Weighted Average Remaining Contractual Term Number of shares, outstanding Share based compensation arrangement by share based payment award equity instrument other than options expected to vest number. Number of Units, Outstanding, Beginning balance Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number Number of Units, Vested Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Number of Units, Forfeited Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited In Period Number of Units, Outstanding, Ending balance Number of Units, Expected to Vest Share Based Compensation Arrangement By Share Based Payment Award Equity Instrument Other Than Options Expected To Vest Number Share based compensation arrangement by share based payment award equity instruments other than options, expected to vest, weighted average grant date fair value. Weighted Average Fair Value per Unit, Outstanding Beginning Balance Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value Weighted Average Fair Value per Unit, Vested Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value Weighted Average Fair Value per Unit, Forfeited Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeitures Weighted Average Grant Date Fair Value Weighted Average Fair Value per Unit, Outstanding Ending Balance Weighted Average Fair Value per Unit, Expected to Vest Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Expected To Vest Weighted Average Grant Date Fair Value Share based compensation arrangement by share based payment award equity instruments other than options aggregate fair value vested. Share based compensation arrangement by share based payment award equity instruments other than options aggregate fair value forfeited. Share based compensation arrangement by share based payment award equity instruments other than options aggregate fair value. Share based compensation arrangement by share based payment award equity instruments other than options aggregate fair value expect to vest. Aggregate Fair Value, Outstanding, Beginning balance Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Aggregate Fair Value Aggregate Fair Value, Vested Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Aggregate Fair Value Vested Aggregate Fair Value, Forfeited Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Aggregate Fair Value Forfeited Aggregate Fair Value, Outstanding, Ending balance Aggregate Fair Value, Expected to Vest Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Aggregate Fair Value Expect To Vest Employee service share based compensation nonvested awards unrecognized compensation cost vesting date. Unrecognized compensation expense Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Share Based Awards Other Than Options Vesting period Employee Service Share Based Compensation Nonvested Awards Unrecognized Compensation Cost Vesting Date Prefunded warrant expiration date. Pre funded warrants expire date Prefunded Warrant Expiration Date Warrants outstanding Class Of Warrant Or Right Outstanding Revenue allowances and reserves provision related to current period sales. Revenue allowances and reserves deductions. Revenue allowance and reserves balance. Valuation And Qualifying Accounts Disclosure [Table] Valuation And Qualifying Accounts Disclosure [Table] SEC Schedule, 12-09, Valuation Allowances and Reserves Type Valuation Allowances And Reserves Type [Axis] SEC Schedule, 12-09, Valuation Allowances and Reserves Valuation Allowances And Reserves [Domain] Chargebacks and cash discount. Chargebacks and Cash Discount Chargebacks And Cash Discount [Member] Distribution fees, rebates and patient assistance. Distribution Fees, Rebates and Patient Assistance Distribution Fees Rebates And Patient Assistance [Member] Valuation And Qualifying Accounts Disclosure [Line Items] Valuation And Qualifying Accounts Disclosure [Line Items] Beginning balance Revenue Allowance And Reserves Balance Provision related to current period sales Revenue Allowance And Reserves Provision Related To Current Period Sales Credit or payments made during the period Revenue Allowances And Reserves Deductions Ending balance