

<!-- DFS ActiveDisclosure(SM) XBRL Schema Document - http://www.dfsco.com/financial-services/ -->
<!-- Creation Date      : 2017-03-31T13:20:55.0914796+00:00 -->
<!-- Version            : 2.4.1.13 -->
<!-- Package ID         : 0C86A299B80B6ACB8C95AEBB5D8821B3-0001671584-001702 -->
<!-- Copyright (c) 2017 Donnelley Financial, LLC. All Rights Reserved. -->
<schema xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:us-types="http://fasb.org/us-types/2016-01-31" xmlns:stpr="http://xbrl.sec.gov/stpr/2011-01-31" xmlns:naics="http://xbrl.sec.gov/naics/2011-01-31" xmlns:apvo="http://www.aptevotherapeutics.com/20161231" xmlns:sic="http://xbrl.sec.gov/sic/2011-01-31" xmlns:invest="http://xbrl.sec.gov/invest/2013-01-31" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:us-gaap="http://fasb.org/us-gaap/2016-01-31" xmlns:dei="http://xbrl.sec.gov/dei/2014-01-31" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:country="http://xbrl.sec.gov/country/2016-01-31" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:currency="http://xbrl.sec.gov/currency/2016-01-31" xmlns:exch="http://xbrl.sec.gov/exch/2016-01-31" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.aptevotherapeutics.com/20161231" xmlns="http://www.w3.org/2001/XMLSchema">
  <import schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/instance" />
  <import schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/linkbase" />
  <import schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" namespace="http://xbrl.org/2005/xbrldt" />
  <import schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" namespace="http://www.xbrl.org/dtr/type/numeric" />
  <import schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" namespace="http://www.xbrl.org/dtr/type/non-numeric" />
  <import schemaLocation="http://xbrl.fasb.org/us-gaap/2016/elts/us-types-2016-01-31.xsd" namespace="http://fasb.org/us-types/2016-01-31" />
  <import schemaLocation="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd" namespace="http://fasb.org/us-gaap/2016-01-31" />
  <import schemaLocation="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd" namespace="http://xbrl.sec.gov/dei/2014-01-31" />
  <import schemaLocation="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd" namespace="http://xbrl.sec.gov/country/2016-01-31" />
  <import schemaLocation="http://xbrl.sec.gov/currency/2016/currency-2016-01-31.xsd" namespace="http://xbrl.sec.gov/currency/2016-01-31" />
  <import schemaLocation="http://xbrl.sec.gov/exch/2016/exch-2016-01-31.xsd" namespace="http://xbrl.sec.gov/exch/2016-01-31" />
  <import schemaLocation="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd" namespace="http://xbrl.sec.gov/invest/2013-01-31" />
  <import schemaLocation="http://xbrl.sec.gov/naics/2011/naics-2011-01-31.xsd" namespace="http://xbrl.sec.gov/naics/2011-01-31" />
  <import schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd" namespace="http://xbrl.sec.gov/sic/2011-01-31" />
  <import schemaLocation="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd" namespace="http://xbrl.sec.gov/stpr/2011-01-31" />
  <annotation>
    <appinfo>
      <link:roleType id="TemplateLink" roleURI="http://www.aptevotherapeutics.com/20161231/role/TemplateLink" xmlns:link="http://www.xbrl.org/2003/linkbase">
        <link:definition>00000 - Document - Template Link</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="apvo-20161231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:title="Calculation Links, all" xlink:type="simple" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="apvo-20161231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:title="Definition Links, all" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="apvo-20161231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:title="Label Links, all" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="apvo-20161231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:title="Presentation Links, all" xlink:type="simple" />
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DocumentDocumentAndEntityInformation" id="Role_DocumentDocumentAndEntityInformation">
        <link:definition>100000 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/StatementCONSOLIDATEDBALANCESHEETS" id="Role_StatementCONSOLIDATEDBALANCESHEETS">
        <link:definition>100010 - Statement - CONSOLIDATED BALANCE SHEETS</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/StatementCONSOLIDATEDBALANCESHEETSParenthetical" id="Role_StatementCONSOLIDATEDBALANCESHEETSParenthetical">
        <link:definition>100020 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/StatementCONSOLIDATEDSTATEMENTSOFOPERATIONS" id="Role_StatementCONSOLIDATEDSTATEMENTSOFOPERATIONS">
        <link:definition>100030 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/StatementCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS" id="Role_StatementCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS">
        <link:definition>100040 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/StatementCONSOLIDATEDSTATEMENTSOFCASHFLOWS" id="Role_StatementCONSOLIDATEDSTATEMENTSOFCASHFLOWS">
        <link:definition>100050 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/StatementCONSOLIDATEDSTATEMENTOFCHANGESINSTOCKHOLDERSEQUITY" id="Role_StatementCONSOLIDATEDSTATEMENTOFCHANGESINSTOCKHOLDERSEQUITY">
        <link:definition>100060 - Statement - CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS EQUITY</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureNatureOfBusinessAndSignificantAccountingPolicies" id="Role_DisclosureNatureOfBusinessAndSignificantAccountingPolicies">
        <link:definition>100070 - Disclosure - Nature of Business and Significant Accounting Policies</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureRestatement" id="Role_DisclosureRestatement">
        <link:definition>100080 - Disclosure - Restatement</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureMorphosysCollaborationAgreement" id="Role_DisclosureMorphosysCollaborationAgreement">
        <link:definition>100090 - Disclosure - MorphoSys Collaboration Agreement</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureFairValueMeasurements" id="Role_DisclosureFairValueMeasurements">
        <link:definition>100100 - Disclosure - Fair Value Measurements</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureInvestments" id="Role_DisclosureInvestments">
        <link:definition>100110 - Disclosure - Investments</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureInventories" id="Role_DisclosureInventories">
        <link:definition>100120 - Disclosure - Inventories</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosurePropertyAndEquipmentNet" id="Role_DisclosurePropertyAndEquipmentNet">
        <link:definition>100130 - Disclosure - Property and Equipment, Net</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureImpairmentOfIntangibleAssetsInProcessResearchAndDevelopmentAndGoodwill" id="Role_DisclosureImpairmentOfIntangibleAssetsInProcessResearchAndDevelopmentAndGoodwill">
        <link:definition>100140 - Disclosure - Impairment of Intangible Assets, In-Process Research and Development and Goodwill</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureIntangibleAssetsNet" id="Role_DisclosureIntangibleAssetsNet">
        <link:definition>100150 - Disclosure - Intangible Assets, Net</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureDebt" id="Role_DisclosureDebt">
        <link:definition>100160 - Disclosure - Debt</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureNetLossPerShare" id="Role_DisclosureNetLossPerShare">
        <link:definition>100170 - Disclosure - Net Loss Per Share</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureEquity" id="Role_DisclosureEquity">
        <link:definition>100180 - Disclosure - Equity</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/Disclosure401KSavingsPlan" id="Role_Disclosure401KSavingsPlan">
        <link:definition>100190 - Disclosure - 401(K) Savings Plan</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureLeasesAndContingencies" id="Role_DisclosureLeasesAndContingencies">
        <link:definition>100200 - Disclosure - Leases and Contingencies</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureIncomeTaxes" id="Role_DisclosureIncomeTaxes">
        <link:definition>100210 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureSubsequentEvents" id="Role_DisclosureSubsequentEvents">
        <link:definition>100220 - Disclosure - Subsequent Events</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureSelectedQuarterlyFinancialDataUnaudited" id="Role_DisclosureSelectedQuarterlyFinancialDataUnaudited">
        <link:definition>100230 - Disclosure - Selected Quarterly Financial Data (unaudited)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureNatureOfBusinessAndSignificantAccountingPoliciesPolicies" id="Role_DisclosureNatureOfBusinessAndSignificantAccountingPoliciesPolicies">
        <link:definition>100240 - Disclosure - Nature of Business and Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureNatureOfBusinessAndSignificantAccountingPoliciesTables" id="Role_DisclosureNatureOfBusinessAndSignificantAccountingPoliciesTables">
        <link:definition>100250 - Disclosure - Nature of Business and Significant Accounting Policies (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureRestatementTables" id="Role_DisclosureRestatementTables">
        <link:definition>100260 - Disclosure - Restatement (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureFairValueMeasurementsTables" id="Role_DisclosureFairValueMeasurementsTables">
        <link:definition>100270 - Disclosure - Fair Value Measurements (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureInvestmentsTables" id="Role_DisclosureInvestmentsTables">
        <link:definition>100280 - Disclosure - Investments (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureInventoriesTables" id="Role_DisclosureInventoriesTables">
        <link:definition>100290 - Disclosure - Inventories (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosurePropertyAndEquipmentNetTables" id="Role_DisclosurePropertyAndEquipmentNetTables">
        <link:definition>100300 - Disclosure - Property and Equipment, Net (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureIntangibleAssetsNetTables" id="Role_DisclosureIntangibleAssetsNetTables">
        <link:definition>100310 - Disclosure - Intangible Assets, Net (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureDebtTables" id="Role_DisclosureDebtTables">
        <link:definition>100320 - Disclosure - Debt (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureNetLossPerShareTables" id="Role_DisclosureNetLossPerShareTables">
        <link:definition>100330 - Disclosure - Net Loss Per Share (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureEquityTables" id="Role_DisclosureEquityTables">
        <link:definition>100340 - Disclosure - Equity (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureLeasesAndContingenciesTables" id="Role_DisclosureLeasesAndContingenciesTables">
        <link:definition>100350 - Disclosure - Leases and Contingencies (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureIncomeTaxesTables" id="Role_DisclosureIncomeTaxesTables">
        <link:definition>100360 - Disclosure - Income Taxes (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureSelectedQuarterlyFinancialDataUnauditedTables" id="Role_DisclosureSelectedQuarterlyFinancialDataUnauditedTables">
        <link:definition>100370 - Disclosure - Selected Quarterly Financial Data (unaudited) (Tables)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureNatureOfBusinessAndSignificantAccountingPoliciesAdditionalInformationDetails" id="Role_DisclosureNatureOfBusinessAndSignificantAccountingPoliciesAdditionalInformationDetails">
        <link:definition>100380 - Disclosure - Nature of Business and Significant Accounting Policies - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureNatureOfBusinessAndSignificantAccountingPoliciesScheduleOfEstimatedUsefulLivesOfPropertyAndEquipmentDetails" id="Role_DisclosureNatureOfBusinessAndSignificantAccountingPoliciesScheduleOfEstimatedUsefulLivesOfPropertyAndEquipmentDetails">
        <link:definition>100390 - Disclosure - Nature of Business and Significant Accounting Policies - Schedule of Estimated Useful Lives of Property and Equipment (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureRestatementAdditionalInformationDetails" id="Role_DisclosureRestatementAdditionalInformationDetails">
        <link:definition>100400 - Disclosure - Restatement - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureRestatementBalanceSheetImpactDetails" id="Role_DisclosureRestatementBalanceSheetImpactDetails">
        <link:definition>100410 - Disclosure - Restatement - Balance Sheet Impact (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureMorphosysCollaborationAgreementAdditionalInformationDetails" id="Role_DisclosureMorphosysCollaborationAgreementAdditionalInformationDetails">
        <link:definition>100420 - Disclosure - MorphoSys Collaboration Agreement - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureFairValueMeasurementsAdditionalInformationDetails" id="Role_DisclosureFairValueMeasurementsAdditionalInformationDetails">
        <link:definition>100430 - Disclosure - Fair Value Measurements - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureFairValueMeasurementsSummaryOfFinancialAssetsMeasuredAtFairValueDetails" id="Role_DisclosureFairValueMeasurementsSummaryOfFinancialAssetsMeasuredAtFairValueDetails">
        <link:definition>100440 - Disclosure - Fair Value Measurements - Summary of Financial Assets Measured at Fair Value (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureFairValueMeasurementsSummaryOfReconciliationOfLiabilitiesMeasuredAtFairValueUsingSignificantUnobservableInputsLevel3Details" id="Role_DisclosureFairValueMeasurementsSummaryOfReconciliationOfLiabilitiesMeasuredAtFairValueUsingSignificantUnobservableInputsLevel3Details">
        <link:definition>100450 - Disclosure - Fair Value Measurements - Summary of Reconciliation of Liabilities Measured at Fair Value Using Significant Unobservable Inputs (Level 3) (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureInvestmentsScheduleOfShortTermInvestmentsDetails" id="Role_DisclosureInvestmentsScheduleOfShortTermInvestmentsDetails">
        <link:definition>100460 - Disclosure - Investments - Schedule of Short-term Investments (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureInventoriesScheduleOfInventoriesDetails" id="Role_DisclosureInventoriesScheduleOfInventoriesDetails">
        <link:definition>100470 - Disclosure - Inventories - Schedule of Inventories (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureInventoriesAdditionalInformationDetails" id="Role_DisclosureInventoriesAdditionalInformationDetails">
        <link:definition>100480 - Disclosure - Inventories - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosurePropertyAndEquipmentNetSummaryOfPropertyPlantAndEquipmentDetails" id="Role_DisclosurePropertyAndEquipmentNetSummaryOfPropertyPlantAndEquipmentDetails">
        <link:definition>100490 - Disclosure - Property and Equipment, Net - Summary of Property, Plant and Equipment (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureImpairmentOfIntangibleAssetsInProcessResearchAndDevelopmentAndGoodwillAdditionalInformationDetails" id="Role_DisclosureImpairmentOfIntangibleAssetsInProcessResearchAndDevelopmentAndGoodwillAdditionalInformationDetails">
        <link:definition>100500 - Disclosure - Impairment of Intangible Assets, In-Process Research and Development and Goodwill - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureIntangibleAssetsNetAdditionalInformationDetails" id="Role_DisclosureIntangibleAssetsNetAdditionalInformationDetails">
        <link:definition>100510 - Disclosure - Intangible Assets, Net - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureIntangibleAssetsNetScheduleOfFutureAmortizationExpenseDetails" id="Role_DisclosureIntangibleAssetsNetScheduleOfFutureAmortizationExpenseDetails">
        <link:definition>100520 - Disclosure - Intangible Assets, Net - Schedule of Future Amortization Expense (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureDebtAdditionalInformationDetails" id="Role_DisclosureDebtAdditionalInformationDetails">
        <link:definition>100530 - Disclosure - Debt - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureDebtScheduleOfFiveYearPaymentsOnDebtDetails" id="Role_DisclosureDebtScheduleOfFiveYearPaymentsOnDebtDetails">
        <link:definition>100540 - Disclosure - Debt - Schedule of Five Year Payments on Debt (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureNetLossPerShareAdditionalInformationDetails" id="Role_DisclosureNetLossPerShareAdditionalInformationDetails">
        <link:definition>100550 - Disclosure - Net Loss Per Share - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureNetLossPerShareSummaryOfPotentiallyDilutiveSharesExcludedFromCalculationOfNetLossPerShareDetails" id="Role_DisclosureNetLossPerShareSummaryOfPotentiallyDilutiveSharesExcludedFromCalculationOfNetLossPerShareDetails">
        <link:definition>100560 - Disclosure - Net Loss Per Share - Summary of Potentially Dilutive Shares Excluded from Calculation of Net Loss Per Share (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureEquityAdditionalInformationDetails" id="Role_DisclosureEquityAdditionalInformationDetails">
        <link:definition>100570 - Disclosure - Equity - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureEquitySummaryOfStockBasedCompensationExpenseIncludesAmortizationOfStockOptionsAndRestrictedStockUnitsGrantedDetails" id="Role_DisclosureEquitySummaryOfStockBasedCompensationExpenseIncludesAmortizationOfStockOptionsAndRestrictedStockUnitsGrantedDetails">
        <link:definition>100580 - Disclosure - Equity - Summary of Stock-based Compensation Expense Includes Amortization of Stock Options and Restricted Stock Units Granted (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureEquityAssumptionsUsedInValuingStockOptionsGrantedUnderBlackScholesValuationModelDetails" id="Role_DisclosureEquityAssumptionsUsedInValuingStockOptionsGrantedUnderBlackScholesValuationModelDetails">
        <link:definition>100590 - Disclosure - Equity - Assumptions used in Valuing the Stock Options Granted under Black-Scholes Valuation Model (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureEquitySummaryOfStockOptionActivityDetails" id="Role_DisclosureEquitySummaryOfStockOptionActivityDetails">
        <link:definition>100600 - Disclosure - Equity - Summary of Stock Option Activity (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureEquitySummaryOfRestrictedStockActivityDetails" id="Role_DisclosureEquitySummaryOfRestrictedStockActivityDetails">
        <link:definition>100610 - Disclosure - Equity - Summary of Restricted Stock Activity (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/Disclosure401KSavingsPlanAdditionalInformationDetails" id="Role_Disclosure401KSavingsPlanAdditionalInformationDetails">
        <link:definition>100620 - Disclosure - 401(K) Savings Plan - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureLeasesAndContingenciesAdditionalInformationDetails" id="Role_DisclosureLeasesAndContingenciesAdditionalInformationDetails">
        <link:definition>100630 - Disclosure - Leases and Contingencies - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureLeasesAndContingenciesSummaryOfFutureMinimumLeasePaymentsUnderOperatingLeaseAgreementsDetails" id="Role_DisclosureLeasesAndContingenciesSummaryOfFutureMinimumLeasePaymentsUnderOperatingLeaseAgreementsDetails">
        <link:definition>100640 - Disclosure - Leases and Contingencies - Summary of Future Minimum Lease Payments Under Operating Lease Agreements (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureIncomeTaxesSummaryOfSignificantComponentsOfProvisionsForIncomeTaxesAttributableToOperationsDetails" id="Role_DisclosureIncomeTaxesSummaryOfSignificantComponentsOfProvisionsForIncomeTaxesAttributableToOperationsDetails">
        <link:definition>100650 - Disclosure - Income Taxes - Summary of Significant Components of Provisions for Income Taxes Attributable to Operations (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureIncomeTaxesScheduleOfNetDeferredTaxAssetLiabilityDetails" id="Role_DisclosureIncomeTaxesScheduleOfNetDeferredTaxAssetLiabilityDetails">
        <link:definition>100660 - Disclosure - Income Taxes - Schedule of Net Deferred Tax Asset (Liability) (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureIncomeTaxesAdditionalInformationDetails" id="Role_DisclosureIncomeTaxesAdditionalInformationDetails">
        <link:definition>100670 - Disclosure - Income Taxes - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureIncomeTaxesScheduleOfReconciliationOfUnrecognizedTaxBenefitsDetails" id="Role_DisclosureIncomeTaxesScheduleOfReconciliationOfUnrecognizedTaxBenefitsDetails">
        <link:definition>100680 - Disclosure - Income Taxes - Schedule of Reconciliation of Unrecognized Tax Benefits (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureIncomeTaxesScheduleOfBenefitFromIncomeTaxesDiffersFromAmountOfTaxesDeterminedByApplyingUSFederalStatuaryRateToLossBeforeBenefitFromIncomeTaxesDetails" id="Role_DisclosureIncomeTaxesScheduleOfBenefitFromIncomeTaxesDiffersFromAmountOfTaxesDeterminedByApplyingUSFederalStatuaryRateToLossBeforeBenefitFromIncomeTaxesDetails">
        <link:definition>100690 - Disclosure - Income Taxes - Schedule of Benefit from Income Taxes Differs from Amount of Taxes Determined by Applying U.S. Federal Statuary Rate to Loss before Benefit from Income Taxes (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureSubsequentEventsAdditionalInformationDetails" id="Role_DisclosureSubsequentEventsAdditionalInformationDetails">
        <link:definition>100700 - Disclosure - Subsequent Events - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureSelectedQuarterlyFinancialDataUnauditedAdditionalInformationDetails" id="Role_DisclosureSelectedQuarterlyFinancialDataUnauditedAdditionalInformationDetails">
        <link:definition>100710 - Disclosure - Selected Quarterly Financial Data (unaudited) - Additional Information (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureSelectedQuarterlyFinancialDataUnauditedBalanceSheetImpactDetails" id="Role_DisclosureSelectedQuarterlyFinancialDataUnauditedBalanceSheetImpactDetails">
        <link:definition>100720 - Disclosure - Selected Quarterly Financial Data (unaudited) - Balance Sheet Impact (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureSelectedQuarterlyFinancialDataUnauditedIncomeStatementImpactDetails" id="Role_DisclosureSelectedQuarterlyFinancialDataUnauditedIncomeStatementImpactDetails">
        <link:definition>100730 - Disclosure - Selected Quarterly Financial Data (unaudited) - Income Statement Impact (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureSelectedQuarterlyFinancialDataUnauditedUnauditedQuarterlyConsolidatedStatementOfOperationsDataDetails" id="Role_DisclosureSelectedQuarterlyFinancialDataUnauditedUnauditedQuarterlyConsolidatedStatementOfOperationsDataDetails">
        <link:definition>100740 - Disclosure - Selected Quarterly Financial Data (unaudited) - Unaudited Quarterly Consolidated Statement of Operations Data (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.aptevotherapeutics.com/20161231/taxonomy/role/DisclosureSelectedQuarterlyFinancialDataUnauditedUnauditedQuarterlyConsolidatedStatementOfOperationsDataParentheticalDetails" id="Role_DisclosureSelectedQuarterlyFinancialDataUnauditedUnauditedQuarterlyConsolidatedStatementOfOperationsDataParentheticalDetails">
        <link:definition>100750 - Disclosure - Selected Quarterly Financial Data (unaudited) - Unaudited Quarterly Consolidated Statement of Operations Data (Parenthetical) (Details)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </appinfo>
  </annotation>
  <element id="apvo_IncomeTaxReconciliationSeparationRelatedAdjustment" name="IncomeTaxReconciliationSeparationRelatedAdjustment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_UnrecognizedTaxBenefitsIncreasesDecreasesResultingFromPriorPeriodTaxPositions" name="UnrecognizedTaxBenefitsIncreasesDecreasesResultingFromPriorPeriodTaxPositions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_IncomeTaxReconciliationPermanentDifferences" name="IncomeTaxReconciliationPermanentDifferences" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_DocumentAndEntityInformationAbstract" name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_InProcessResearchAndDevelopment" name="InProcessResearchAndDevelopment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_IntangibleAssetsNetExcludingGoodwillAndInProcessResearchAndDevelopment" name="IntangibleAssetsNetExcludingGoodwillAndInProcessResearchAndDevelopment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_SalesRebatesAndDiscounts" name="SalesRebatesAndDiscounts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_ContributionReceivableFromFormerParent" name="ContributionReceivableFromFormerParent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_FormerParentInvestmentInSubsidiary" name="FormerParentInvestmentInSubsidiary" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_CollaborationsRevenue" name="CollaborationsRevenue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_RestrictedCash" name="RestrictedCash" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_IncreaseDecreaseInSalesRebatesAndDiscounts" name="IncreaseDecreaseInSalesRebatesAndDiscounts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_ContingentConsiderationPayments" name="ContingentConsiderationPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_StockholdersEquityNetTransfersFromFormerParent" name="StockholdersEquityNetTransfersFromFormerParent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_StockholdersEquityNoteSpinoffTransactionShares" name="StockholdersEquityNoteSpinoffTransactionShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_FormerParentInvestmentInSubsidiaryMember" name="FormerParentInvestmentInSubsidiaryMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_ContributionReceivableFromFormerParentMember" name="ContributionReceivableFromFormerParentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_ShortTermInvestmentPolicyTextBlock" name="ShortTermInvestmentPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_PropertyPlantAndEquipmentUsefulLifeTableTextBlock" name="PropertyPlantAndEquipmentUsefulLifeTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_ScheduleOfPrincipalAndInterestPaymentsOnDebtTableTextBlock" name="ScheduleOfPrincipalAndInterestPaymentsOnDebtTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_BalanceSheetsRestatementMember" name="BalanceSheetsRestatementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_StatementOfOperationRestatementMember" name="StatementOfOperationRestatementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_NatureOfBusinessLineItems" name="NatureOfBusinessLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_NatureOfBusinessTable" name="NatureOfBusinessTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_EmergentBioSolutionsIncMember" name="EmergentBioSolutionsIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_CreditFacilityFirstTrancheMember" name="CreditFacilityFirstTrancheMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_CreditFacilitySecondTrancheMember" name="CreditFacilitySecondTrancheMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_PromissoryNoteMember" name="PromissoryNoteMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_RestrictedStockUnitsAndOptionsMember" name="RestrictedStockUnitsAndOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_DateOfSpinoff" name="DateOfSpinoff" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_ProceedsFromPaymentForFormerParentUponSpinOffNetOfReceivable" name="ProceedsFromPaymentForFormerParentUponSpinOffNetOfReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_StockholdersEquityNetTransfersOfCashFromFormerParent" name="StockholdersEquityNetTransfersOfCashFromFormerParent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_NoncashTransferOfIntangibleAsset" name="NoncashTransferOfIntangibleAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_WorkingCapitalReimbursementForOutstandingPaymentsReceivable" name="WorkingCapitalReimbursementForOutstandingPaymentsReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_NumberOfDistributorsRelatedToSalesAgreement" name="NumberOfDistributorsRelatedToSalesAgreement" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_SoftwareAndHardwareMember" name="SoftwareAndHardwareMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardForfeitureRate" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardForfeitureRate" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_TurbionPharmaceuticalsIncMember" name="TurbionPharmaceuticalsIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_AdditionalContingentPayment" name="AdditionalContingentPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_FirstContingentPaymentBasedUponDevelopmentAndRegulatoryMilestones" name="FirstContingentPaymentBasedUponDevelopmentAndRegulatoryMilestones" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_SecondContingentPaymentReceivedBasedUponDevelopmentAndRegulatoryMilestones" name="SecondContingentPaymentReceivedBasedUponDevelopmentAndRegulatoryMilestones" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_MaximumFundingRequirementCap" name="MaximumFundingRequirementCap" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_MaximumPercentageOfTieredRoyaltyObligationOnSales" name="MaximumPercentageOfTieredRoyaltyObligationOnSales" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_ShareOfJointDevelopmentCostsPercentage" name="ShareOfJointDevelopmentCostsPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_AptevoMember" name="AptevoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_MorphosysAgreementMember" name="MorphosysAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_MorphosysMember" name="MorphosysMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_MorphosysAgreementJanuaryOneTwoThousandSeventeenThroughJuneThirtyTwoThousandSeventeenMember" name="MorphosysAgreementJanuaryOneTwoThousandSeventeenThroughJuneThirtyTwoThousandSeventeenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_MorphosysAgreementJulyOneTwoThousandSeventeenThroughDecemberThirtyOneTwoThousandEighteenMember" name="MorphosysAgreementJulyOneTwoThousandSeventeenThroughDecemberThirtyOneTwoThousandEighteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_MorphosysAgreementTwoThousandNineteenAndBeyondMember" name="MorphosysAgreementTwoThousandNineteenAndBeyondMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_CollaborativeArrangementsNumberOfUnitsOfAccounting" name="CollaborativeArrangementsNumberOfUnitsOfAccounting" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_CurrentEstimatedServicePeriodForUndeliveredDevelopmentServices" name="CurrentEstimatedServicePeriodForUndeliveredDevelopmentServices" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_AllocationOfCollaborativeArrangementsUpfrontPaymentToUnitsOfAccounting" name="AllocationOfCollaborativeArrangementsUpfrontPaymentToUnitsOfAccounting" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_UpfrontPaymentAllocatedToLicenseFeeUnit" name="UpfrontPaymentAllocatedToLicenseFeeUnit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_UpfrontPaymentAllocatedToServiceDevelopment" name="UpfrontPaymentAllocatedToServiceDevelopment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_CorporateBondsMember" name="CorporateBondsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_RoyaltyAgreementExpirationDate" name="RoyaltyAgreementExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_FutureRoyaltyPaymentsExpected" name="FutureRoyaltyPaymentsExpected" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_FiniteLivedIntangibleAssetsAmortizationExpenseYearFiveAndAfter" name="FiniteLivedIntangibleAssetsAmortizationExpenseYearFiveAndAfter" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_NonNegotiableUnsecuredPromissoryNoteMember" name="NonNegotiableUnsecuredPromissoryNoteMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_PaymentOfPrincipalAndInterestOnDebtInNextTwelveMonths" name="PaymentOfPrincipalAndInterestOnDebtInNextTwelveMonths" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_PaymentOfPrincipalAndInterestOnDebtInYearTwo" name="PaymentOfPrincipalAndInterestOnDebtInYearTwo" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_PaymentOfPrincipalAndInterestOnDebtInYearThree" name="PaymentOfPrincipalAndInterestOnDebtInYearThree" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_PaymentOfPrincipalAndInterestOnDebtInYearFour" name="PaymentOfPrincipalAndInterestOnDebtInYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_PaymentOfPrincipalAndInterestOnDebtInYearFive" name="PaymentOfPrincipalAndInterestOnDebtInYearFive" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_PaymentOfPrincipalAndInterestOnDebt" name="PaymentOfPrincipalAndInterestOnDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_CreditAgreementExitFeePercentage" name="CreditAgreementExitFeePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_CreditAgreementPrepaymentFeePercentageForFirstYear" name="CreditAgreementPrepaymentFeePercentageForFirstYear" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_ScheduleOfEarningsPerShareBasicAndDilutedLineItems" name="ScheduleOfEarningsPerShareBasicAndDilutedLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_ScheduleOfEarningsPerShareBasicAndDilutedTable" name="ScheduleOfEarningsPerShareBasicAndDilutedTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_ConvertedEquityAwardsIncentivePlanMember" name="ConvertedEquityAwardsIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_TwoThousandSixteenStockIncentivePlanMember" name="TwoThousandSixteenStockIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_NonEmployeeDirectorsMember" name="NonEmployeeDirectorsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateImpactOfConversionRelatedToSpinOff" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateImpactOfConversionRelatedToSpinOff" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateImpactOfConversionRelatedToSpinoffWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateImpactOfConversionRelatedToSpinoffWeightedAverageExercisePrice" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateImpactOfConversionRelatedToSpinOffIntrinsicValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateImpactOfConversionRelatedToSpinOffIntrinsicValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantedIntrinsicValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantedIntrinsicValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriodIntrinsicValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriodIntrinsicValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExpectedToVestWeightedAveragePeriod" name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExpectedToVestWeightedAveragePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAndExercisableWeightedAverageRemainingContractualTerm" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAndExercisableWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateImpactOfConversionRelatedToSpinOffInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateImpactOfConversionRelatedToSpinOffInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsExpectedToVestNumber" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsExpectedToVestNumber" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateImpactOfConversionRelatedToSpinOffInPeriodWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateImpactOfConversionRelatedToSpinOffInPeriodWeightedAverageGrantDateFairValue" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedWeightedAverageGrantDateFairValue" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateImpactOfConversionRelatedToSpinoff" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateImpactOfConversionRelatedToSpinoff" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateFairValueGranted" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateFairValueGranted" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateFairValueConverted" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateFairValueConverted" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateFairValueForfeited" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateFairValueForfeited" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateFairValueExpectToVest" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateFairValueExpectToVest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_FederalNetOperatingLoss" name="FederalNetOperatingLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_OperatingLossCarryforwardsExpirationYear" name="OperatingLossCarryforwardsExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_TaxCreditCarryforwardExpirationYear" name="TaxCreditCarryforwardExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="apvo_StateTaxLosses" name="StateTaxLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_IncomeTaxesLineItems" name="IncomeTaxesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_IncomeTaxesTable" name="IncomeTaxesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_UnrecognizedTaxBenefitsIncreasesDecreasesResultingFromCurrentPeriodTaxPositions" name="UnrecognizedTaxBenefitsIncreasesDecreasesResultingFromCurrentPeriodTaxPositions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="apvo_PaymentsReceivedFromRelatedParties" name="PaymentsReceivedFromRelatedParties" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <element id="apvo_SelectedQuarterlyFinancialDataLineItems" name="SelectedQuarterlyFinancialDataLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="apvo_SelectedQuarterlyFinancialDataTable" name="SelectedQuarterlyFinancialDataTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
</schema>





