100000 - Document - Document and Entity Information
link:presentationLink
link:calculationLink
link:definitionLink
100010 - Statement - CONSOLIDATED BALANCE SHEETS
link:presentationLink
link:calculationLink
link:definitionLink
100020 - Disclosure - Cash and Cash Equivalents - Schedule of Cash and Cash Equivalents (Details) 2
link:presentationLink
link:calculationLink
link:definitionLink
100030 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
100040 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS
link:presentationLink
link:calculationLink
link:definitionLink
100050 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS
link:presentationLink
link:calculationLink
link:definitionLink
100060 - Statement - CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' EQUITY
link:presentationLink
link:calculationLink
link:definitionLink
100070 - Statement - CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' EQUITY (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
100080 - Disclosure - Nature of Business and Significant Accounting Policies
link:presentationLink
link:calculationLink
link:definitionLink
100090 - Disclosure - Discontinued Operations
link:presentationLink
link:calculationLink
link:definitionLink
100100 - Disclosure - XOMA Transaction
link:presentationLink
link:calculationLink
link:definitionLink
100110 - Disclosure - Collaboration Agreements
link:presentationLink
link:calculationLink
link:definitionLink
100120 - Disclosure - Fair Value Measurements
link:presentationLink
link:calculationLink
link:definitionLink
100130 - Disclosure - Cash and Cash Equivalents
link:presentationLink
link:calculationLink
link:definitionLink
100140 - Disclosure - Property and Equipment, Net
link:presentationLink
link:calculationLink
link:definitionLink
100150 - Disclosure - Debt
link:presentationLink
link:calculationLink
link:definitionLink
100160 - Disclosure - Liability Related to Sale of Royalties
link:presentationLink
link:calculationLink
link:definitionLink
100170 - Disclosure - Leases and Contingencies
link:presentationLink
link:calculationLink
link:definitionLink
100180 - Disclosure - Net Income (Loss) per Share
link:presentationLink
link:calculationLink
link:definitionLink
100190 - Disclosure - Equity
link:presentationLink
link:calculationLink
link:definitionLink
100200 - Disclosure - 401(K) Savings Plan
link:presentationLink
link:calculationLink
link:definitionLink
100210 - Disclosure - Income Taxes
link:presentationLink
link:calculationLink
link:definitionLink
100220 - Disclosure - Subsequent Events
link:presentationLink
link:calculationLink
link:definitionLink
100230 - Disclosure - Nature of Business and Significant Accounting Policies (Policies)
link:presentationLink
link:calculationLink
link:definitionLink
100240 - Disclosure - Nature of Business and Significant Accounting Policies (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
100250 - Disclosure - Discontinued Operations (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
100260 - Disclosure - Cash and Cash Equivalents (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
100270 - Disclosure - Property and Equipment, Net (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
100280 - Disclosure - Debt (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
100290 - Disclosure - Liability Related to Sale of Royalties (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
100300 - Disclosure - Leases and Contingencies (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
100310 - Disclosure - Net Income (Loss) per Share (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
100320 - Disclosure - Equity (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
100330 - Disclosure - Income Taxes (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
100340 - Disclosure - Nature of Business and Significant Accounting Policies - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100350 - Disclosure - Nature of Business and Significant Accounting Policies - Schedule of Estimated Useful Lives of Property and Equipment (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100360 - Disclosure - Discontinued Operations - Summary of Reconciliation of Carrying Amounts of Assets and Liabilities and Income (Loss) from Discontinued Operation (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100370 - Disclosure - Discontinued Operations - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100380 - Disclosure - XOMA Transaction - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100390 - Disclosure - Collaboration Agreements - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100400 - Disclosure - Fair Value Measurements - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100410 - Disclosure - Cash and Cash Equivalents - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100420 - Disclosure - Cash and Cash Equivalents - Schedule of Cash and Cash Equivalents (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100430 - Disclosure - Property and Equipment, Net - Summary of Property and Equipment (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100440 - Disclosure - Property and Equipment, Net - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100450 - Disclosure - Debt - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100460 - Disclosure - Debt - Schedule of Future Principal, Interest, and Other Related Fee Payments in Connection with the Credit Agreement (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100470 - Disclosure - Liability Related to Sale of Royalties - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100480 - Disclosure - Liability Related to Sale of Royalties - Schedule of Changes in the Liability Related to the Sale of Royalties (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100490 - Disclosure - Leases and Contingencies - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100500 - Disclosure - Leases and Contingencies - Components of Lease Expense (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100510 - Disclosure - Leases and Contingencies - Summary of Right of Use Assets Acquired Under Operating Leases (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100520 - Disclosure - Leases and Contingencies - Summary of Future Minimum Lease Payments (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100530 - Disclosure - Leases and Contingencies - Summary of Future Minimum Lease Payments (Details) 2
link:presentationLink
link:calculationLink
link:definitionLink
100540 - Disclosure - Net Income (Loss) Per Share - Computation of Basic and Diluted Net Income (Loss) per Share (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100550 - Disclosure - Net Income (Loss) Per Share - Summary of Potentially Dilutive Shares Excluded from Calculation of Net Loss Per Share (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100560 - Disclosure - Equity - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100570 - Disclosure - Equity - Additional Information (Details1)
link:presentationLink
link:calculationLink
link:definitionLink
100580 - Disclosure - Equity - Summary of Warrant Activity (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100590 - Disclosure - Equity - Assumptions used in Estimating the Incremental Fair Value of the Exchanged Common Warrants under Black-scholes Valuation Model (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100600 - Disclosure - Equity - Summary of Stock-based Compensation Expense Includes Amortization of Stock Options and Restricted Stock Units Granted (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100610 - Disclosure - Equity - Assumptions used in Valuing the Stock Options Granted under Black-Scholes Valuation Model (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100620 - Disclosure - Equity - Summary of Stock Option Activity (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100630 - Disclosure - Equity - Summary of Restricted Stock Activity (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100640 - Disclosure - 401(K) Savings Plan - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100650 - Disclosure - Income Taxes - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100660 - Disclosure - Income Taxes - Schedule of Income (Loss) from Continuing Operations Before Income Taxes (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100670 - Disclosure - Income Taxes - Schedule of Tax Effects of Temporary Differences Give Rise to Significant Portions of Deferred Tax Assets and Deferred Tax Liabilities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100680 - Disclosure - Income Taxes - Schedule of Reconciliation of Federal Statutory Income Tax Rate to Effective Income Tax from Continuing Operations (Details)
link:presentationLink
link:calculationLink
link:definitionLink
100690 - Disclosure - Subsequent Events - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
Auditor Firm ID
Auditor Firm ID
2024
Lessee, Operating Lease, Liability, to be Paid, Year One
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Document Transition Report
Document Transition Report
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Term, Outstanding
Proceeds from exercise of stock options value.
Proceeds From Exercise Of Stock Options Value
Proceeds from exercise of stock options
Royalty Income, Nonoperating
Milestone income related to sale of royalties
Gross proceeds from warrant exercises
Gross proceeds from warrant exercises
Gross proceeds from warrant exercises.
Number of common stock shares to be issued exercise of prefunded warrants.
Number Of Common Stock Shares To Be Issued Exercise Of Prefunded Warrants
Number of common stock to be issued exercise of prefunded warrants
Earnings Per Share, Diluted, Other Disclosure [Abstract]
Diluted shares used in calculation:
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Stock plan vesting period
Increase decrease in operating lease right of use assets.
Increase Decrease In Operating Lease Right Of Use Assets
Operating lease right-of-use asset
Net (loss) income from continuing operations
Net (loss) income from continuing operations
Income (Loss) from Continuing Operations, Net of Tax, Including Portion Attributable to Noncontrolling Interest
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other current assets
Restricted Stock Units (RSUs) [Member]
Unvested RSUs
RSUs
Entity Public Float
Entity Public Float
Expected average life of warrants
Class Of Warrant Or Right Expected Average Life Of Warrants
Class of warrant or right expected average life of warrants.
Gain related to sale of non-financial asset
Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal
Fair Value Disclosures [Text Block]
Fair Value Measurements
Income Tax, Policy [Policy Text Block]
Income Taxes
Property, Plant and Equipment, Useful Life
Estimated useful lives
Revenue from Contract with Customer, Excluding Assessed Tax
Royalty revenue
Share based compensation arrangement by share based payment award equity instrument other than options expected to vest number.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instrument Other Than Options Expected To Vest Number
Number of Units, Expected to Vest
Shares of common stock issued for cash consideration
Shares Of Common Stock Issued For Cash Consideration
Shares of common stock issued for cash consideration.
Liability Related to Sale of Royalties
Liability related to sale of future royalties disclosure.
Liability Related To Sale Of Future Royalties Disclosure [Text Block]
Property plant and equipment useful life.
Property Plant And Equipment Useful Life Table [Text Block]
Schedule of Estimated Useful Lives of Property and Equipment
Increase in valuation allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Credit Agreement
Credit agreement member.
Credit Agreement [Member]
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block]
Nature of Business and Significant Accounting Policies
Proceeds from sale of royalties
Proceeds From Sale Of Royalties
Proceeds from sale of royalties.
Broadridge Corporate Issuer Solutions.
Broadridge Corporate Issuer Solutions [Member]
Broadridge Corporate Issuer Solutions
Title of Individual [Domain]
Title of Individual
Weighted-Average Remaining Term, Exercised
Class Of Warrant Or Right Exercised Weighted Average Remaining Contractual Term
Class of warrant or right exercised weighted average remaining contractual term.
Subsequent Events [Text Block]
Subsequent Events
Deferred payment
Disposal group including discontinued operations deferred revenue.
Disposal Group Including Discontinued Operations Deferred Revenue
Deferred payments from Medexus
August 2023 Common Warrants
August 2023 Common Warrants [Member]
August 2023 common warrants.
Weighted-Average Remaining Term, Exercisable
Class Of Warrant Or Right Exercisable Weighted Average Remaining Contractual Term
Class of warrant or right exercisable weighted average remaining contractual term.
Number of Shares, Issued
Class Of Warrant Or Right Issued
Class of warrant or right issued.
Operating Lease, Liability, Noncurrent
Operating lease liability
Long term portion of operating lease liabilities
Share based compensation arrangement by share based payment award equity instruments other than options, expected to vest, weighted average grant date fair value.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Expected To Vest Weighted Average Grant Date Fair Value
Weighted Average Fair Value per Unit, Expected to Vest
Disposal Groups, Including Discontinued Operations [Table]
Income Statement Balance Sheet And Additional Disclosures By Disposal Groups Including Discontinued Operations [Table]
Liabilities, Fair Value Disclosure
Fair value liabilities
Liabilities, Fair Value Disclosure, Total
Related Party Transactions [Abstract]
Assets, Current
Total current assets
Vesting [Domain]
Vesting
Liabilities and Equity
Total liabilities and stockholders' equity
Entity Address, State or Province
Entity Address, State or Province
Deferred Tax Assets, Other
Other deferred tax assets
Commitment shares issued/ proceeds from issuance of common stock
Stock Issued During Period, Value, New Issues
Issuance of common stock, net
Proceeds from issuance of common stock and prefunded warrants
Proceeds from issuance of common stock and prefunded warrants.
Percentage of cost related to research and development
Research And Development Cost Percentage
Research and development cost percentage.
Reverse stock split
Stockholders' Equity Note, Stock Split, Conversion Ratio
Stockholders' Equity Note, Stock Split, Conversion Ratio
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of Shares, Outstanding, Ending balance
Number of Shares, Outstanding, Beginning balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average grant date fair value per share of options granted
Trading Symbol
Trading Symbol
Deferred Tax Assets, Net of Valuation Allowance
Deferred tax assets, net of valuation
Common stock issued
Common Stock, Shares, Issued
Common stock, shares issued
Proceeds from exercises of stock options shares.
Proceeds from exercises of stock options shares
Proceeds from exercise of stock options (in shares)
Proceeds from exercise of stock options (in shares)
Royalty and milestone receivable.
Royalty and Milestone Receivable
Royalty and milestone receivable
Transaction costs for milestones related to sale of royalties
Transaction costs
Transaction Costs For Milestones Related To Sale Of Royalties
Transaction costs for milestones related to sale of royalties.
Cash equivalents maturity period.
Cash Equivalents Maturity Period
Cash equivalents, maturity period
Dividend declared of preferred share purchase right.
Dividend Declared Of Preferred Share Purchase Right
Preferred share purchase right
Schedule of Long-Term Debt Instruments [Table]
Debt Instrument [Table]
Additional amount to be received upon exercise of warrants
Additional Amount To Be Received Upon Exercise Of Warrants
Additional amount to be received upon exercise of warrants.
Shares, Outstanding
Balance (in shares)
Balance (in shares)
2026
Lessee, Operating Lease, Liability, to be Paid, Year Three
Long-Term Debt, Current Maturities
Current portion of long-term debt
Long-Term Debt, Current Maturities, Total
Entity Address, City or Town
Entity Address, City or Town
Related Party Transaction [Line Items]
Operating Lease, Weighted Average Discount Rate, Percent
Weighted discount rate for operating leases
Number of Shares, Outstanding, Ending Balance
Number of Shares, Outstanding, Beginning Balance
Class of Warrant or Right, Outstanding
Warrants outstanding
Lessee, Operating Lease, Renewal Term
Operating lease renewal option term
Debt Disclosure [Text Block]
Debt
Property, Plant and Equipment [Table Text Block]
Summary of Property and Equipment
Number of Shares, Vest and expected to Vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number
Disposal Group Name [Axis]
Subsequent Event [Member]
Subsequent Event
Subsequent Event Type [Axis]
Subsequent Event Type
Finance Lease, Principal Payments
Financing lease payments
Share-Based Payment Arrangement, Tranche Two [Member]
Tranche Two
Additional Paid-in Capital [Member]
Additional Paid-In Capital
Property, Plant, and Equipment, Useful Life, Term, Description [Extensible Enumeration]
Derivative, Fixed Interest Rate
Interest rate
Liabilities, Current [Abstract]
Current liabilities:
Assets, Current [Abstract]
Current assets:
Counterparty Name [Axis]
Counterparty Name
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Cash and Cash Equivalents
Cash and Cash Equivalents Disclosure [Text Block]
2027 and beyond
Lessee operating lease liability payments due year four and beyond.
Lessee Operating Lease Liability Payments Due Year Four and Beyond
Statement of Stockholders' Equity [Abstract]
Operating Lease, Liability, Current
Current portion of operating lease liabilities
Basic and diluted net income per share from discontinued operations.
Basic And Diluted Net Income Per Share From Discontinued Operations [Abstract]
Basic and diluted net income per share from discontinued operations:
Earnings Per Share, Basic, Other Disclosure [Abstract]
Basic shares used in calculation:
Debt outstanding
Long-Term Debt
Total
Percentage of entitlement to receive Canadian approval milestone payment.
Percentage of entitlement to receive Canadian Approval Milestone Payment
Percentage of entitlement to receive Canadian approval milestone payment
Property, Plant and Equipment, Net
Property and equipment, net
Total property and equipment, net
Class of Stock [Domain]
Class of Stock
Reverse stock split description
Stockholders' Equity Note, Stock Split
Software and hardware.
Software And Hardware [Member]
Software and Hardware
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Federal tax at statutory rates
Scenario [Domain]
Scenario
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Entity Central Index Key
Entity Central Index Key
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Number of common stock to be issued up conversion of warrants
Plan Name [Domain]
Plan Name
Schedule of earnings per share basic and diluted.
Schedule Of Earnings Per Share Basic And Diluted [Table]
Schedule Of Earnings Per Share Basic And Diluted [Table]
Deferred tax assets capitalized research expenditures.
Deferred Tax Assets Capitalized Research Expenditures
Capitalized research expenditures
Gain (Loss) on Disposition of Property Plant Equipment, Excluding Oil and Gas Property and Timber Property
Loss on disposal of property and equipment
Assets, Fair Value Disclosure
Fair value assets
Assets, Fair Value Disclosure, Total
Lessee, Operating Lease, Option to Extend
Operating lease renewal option description
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Liabilities, Current
Total current liabilities
Entity Tax Identification Number
Entity Tax Identification Number
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Income (loss) from continuing operations before benefit from income taxes
Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Lincoln Park Member
Lincoln Park [Member]
Lincoln Park
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock-based compensation
Line of Credit Facility [Table]
Line Of Credit Facility [Table]
Schedule of Changes in the Liability Related to the Sale of Royalties
Schedule of changes in the liability related to the sale of future royalties.
Schedule Of Changes In Liability Related To Sale Of Future Royalties Table [Text Block]
Award Type [Axis]
Award Type
Lessee, Operating Leases [Text Block]
Leases and Contingencies
Cash and Cash Equivalents [Abstract]
Plan Name [Axis]
Plan Name
Assets
Total assets
Operating Lease, Right-of-Use Asset
Operating lease right-of-use asset
Total right-of-use assets
Line of Credit Facility [Line Items]
Line Of Credit Facility [Line Items]
Operating lease property number of units.
Operating Lease Property Number Of Lab Equipment
Operating lease number of piece for lab equipment
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Unrecognized compensation expense
Royalty Revenue
Royalty Revenue Policy Policy [Text Block]
Royalty revenue.
Series A
Common Class A [Member]
Entity Registrant Name
Entity Registrant Name
Cash consideration as an initial fee for commitment to purchase shares of common stock.
Cash consideration as an initial fee for commitment to purchase shares of common stock
Cash consideration as an initial fee for commitment to purchase shares of common stock
Lessee, Operating Lease, Existence of Option to Extend [true false]
Operating lease option to extend
Lessee, Lease, Description [Line Items]
Lessee Lease Description [Line Items]
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Supplemental Cash Flow Information [Abstract]
Deferred tax assets gain related to sale of future royalties.
Deferred Tax Assets Gain Related To Sale Of Future Royalties
Gain related to sale of future royalties
Retained Earnings [Member]
Accumulated Deficit
Class of Stock [Axis]
Class of Stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Number of Units, Outstanding, Ending balance
Number of Units, Outstanding, Beginning balance
Warrant Inducement Agreement
Warrant Inducement Agreement [Member]
Warrant inducement agreement.
Minimum [Member]
Minimum
Minimum
Liability related to sale of royalties, beginning balance
Liability related to sale of royalties, ending balance
Liability Related To Sale Of Royalties
Liability related to sale of royalties.
Proceeds from Stock Options Exercised
Proceeds upon exercise of stock options
Proceeds from exercise of stock options
Operating Lease, Liability
Operating lease liability
Total
Operating Lease, Liability, Total
Forecast [Member]
Scenario Forecast
Share-Based Payment Arrangement, Tranche One [Member]
Tranche One
Kamada [Member]
Kamada [Member]
Kamada.
Equity Component [Domain]
Equity Component
Employee Stock Option [Member]
Stock Option
Outstanding Options to Purchase Common Stock
Defined Benefit Plan, Plan Assets, Contributions by Employer
Matching contributions made by employer
Adjustments to reconcile (loss) income to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Debt Disclosure [Abstract]
Entity Current Reporting Status
Entity Current Reporting Status
Common Stock, Shares Authorized
Common stock, shares authorized
Research and Development Expense
Research and development
Research and Development Expense, Total
Debt Extinguishment
Debt, Policy [Policy Text Block]
Debt Issuance Costs
Weighted-Average Exercise Price, Issued
Class Of Warrant Or Right Issued Weighted Average Exercise Price
Class of warrant or right issued weighted average exercise price.
Deferred Tax Liabilities, Gross
Deferred tax liability
Deferred Tax Liabilities, Gross, Total
Disposal Groups, Including Discontinued Operations, Disclosure [Text Block]
Discontinued Operations
Assets [Abstract]
ASSETS
Proceeds from issuance of common stock and prefunded warrants
Proceeds from Issuance of Common Stock
Proceeds from issuance of common stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Number of shares available for grant
Common stock: $0.001 par value; 500,000,000 shares authorized; 19,468,180 and 6,466,294 shares issued and outstanding at December 31, 2023 and December 31, 2022, respectively
Common Stock, Value, Issued
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Change in valuation allowance
Repayments of Long-Term Debt
Repayments of subordinated debt
Repayments of Long-Term Debt, Total
Payments of long-term debt, including fees
Income (Loss) from Continuing Operations, Per Diluted Share
Diluted
Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Diluted Share [Abstract]
Diluted net income per share from discontinued operations:
Shareholders' Equity and Share-Based Payments [Text Block]
Equity
Furniture and Fixtures [Member]
Furniture and Equipment
Current Fiscal Year End Date
Current Fiscal Year End Date
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation
Share-Based Payment Arrangement, Noncash Expense, Total
Auditor Name
Auditor Name
Operating Income (Loss)
Loss from operations
Repayments of Debt
Repayment of debt
Tax Period [Axis]
Tax Period
Debt Issuance Costs, Gross
Transaction costs
Percentage of entitlement to receive deferred payments.
Percentage of entitlement to receive deferred payments
Percentage of entitlement to receive deferred payments
Research and Development Expense [Member]
Research and Development
Cash
Cash
Lessee, Leases [Policy Text Block]
Leases
Effective Income Tax Rate Reconciliation, Tax Expense (Benefit), Share-Based Payment Arrangement, Percent
Stock-based compensation
Share-Based Payment Arrangement, Expense
Stock-based compensation expense
Disposal Groups, Including Discontinued Operations [Table Text Block]
Summary of Reconciliation of Carrying Amounts of Assets and Liabilities and Income (Loss) from Discontinued Operation
Weighted-Average Remaining Term, Issued
Class Of Warrant Or Right Issued Weighted Average Remaining Contractual Term
Class of warrant or right issued weighted average remaining contractual term.
Equipment [Member]
Lab Equipment Lease
Expected dividend yield
Class Of Warrant Or Right Expected Dividend Yield
Class of warrant or right expected dividend yield.
Disposal Group Name [Domain]
Share based compensation arrangement by share based payment award maximum number of returning shares from old plan to be added to shares reserve.
Share Based Compensation Arrangement By Share Based Payment Award Maximum Number Of Returning Shares From Old Plan To Be Added To Shares Reserve
Maximum number of returning shares from old plan to be add to shares reserve
Weighted-Average Exercise Price, Exercisable
Class Of Warrant Or Right Exercisable Weighted Average Exercise Price
Class of warrant or right exercisable weighted average exercise price.
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Outstanding, Ending balance
Aggregate Intrinsic Value, Outstanding, Beginning balance
Proceeds from warrant inducement, net of issuance cost ( in shares)
Proceeds From Issuance Of Warrants Share
Proceeds from issuance of warrants share.
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Other income (expense) from continuing operations, net
Other Nonoperating Income (Expense)
Other Nonoperating Income (Expense), Total
Operating Expenses [Abstract]
Operating expenses:
Property, Plant and Equipment [Abstract]
Entity Voluntary Filers
Entity Voluntary Filers
Warrant modification - incremental value
Warrant modification incremental value
Warrant modification incremental value.
Increase decrease in royalties receivable
Increase Decrease In Royalties Receivable
Royalty receivable
Subsequent Events [Abstract]
Restrictions on Cash and Cash Equivalents [Table]
Schedule Of Restricted Cash And Cash Equivalents [Table]
Payment of amount outstanding.
Payment Of Amount Outstanding
Payment Of Amount Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Number of Shares, Granted
Depreciation
Depreciation expense
Depreciation, Total
Series B
Common Class B [Member]
Gain on contingent consideration
Discontinued Operating Gain on Contingent Consideration.
Discontinued Operating Gain On Contingent Consideration
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price
Weighted-Average Exercise Price, vest and expected to vest
IXINITY.
I X I N I T Y [Member]
IXINITY
Increase decrease in long term operating lease liability.
Increase Decrease In Long Term Operating Lease Liability
Long-term operating lease liability
Share based compensation arrangement by share based payment award forfeiture rate.
Share Based Compensation Arrangement By Share Based Payment Award Forfeiture Rate
Estimated forfeiture rate
Equity, Attributable to Parent [Abstract]
Stockholders' equity:
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Lease, Cost [Table Text Block]
Components of Lease Expense
Entity [Domain]
Entity
Line of Credit Facility, Maximum Borrowing Capacity
Maximum borrowing capacity
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value
Total fair value of stock option vested
Net (loss) income per share:
Earnings Per Share [Abstract]
Series A and Series B Common Warrants
Series A and Series B common warrants [Member]
Series A and Series B common warrants.
Tax credit carryforward, expiration year.
Tax Credit Carryforward Expiration Year
Tax credits, begin to expiration year
Deferred Tax Liabilities, Net
Net deferred tax liabilities
Net deferred tax assets
Accounting Policies [Abstract]
Lessee, Lease, Description [Table]
Lessee Lease Description [Table]
Office space lease.
Office Space Lease [Member]
Office Space Lease
Series A-2 Common Warrants
Series A Two Common Warrants [Member]
Series a two common warrants.
Proceeds from Royalties Received
Proceeds from royalties received
Proceeds from sale of royalties, net of transaction costs
Weighted-Average Exercise Price, Exercised with shares held in abeyance
Class Of Warrant Or Right Exercised With Shares Held In Abeyance Weighted Average Exercise Price
Class of warrant or right exercised with shares held in abeyance weighted average exercise price.
Liability Class [Axis]
Liability Class
Proceeds from exercise of warrants share.
Proceeds From Exercise Of Warrants Share
Proceeds from exercise of warrants (in shares)
Proceeds from exercise of warrants (in shares)
Scenario [Axis]
Scenario
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentrations of Credit Risk
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Shares, Exercised with shares held in abeyance
Class Of Warrant Or Right Exercised With Shares Held In Abeyance
Class of warrant or right exercised with shares held in abeyance.
Two lease renewal option.
Two Lease Renewal Option [Member]
Renewal Option Two
Earnings Per Share, Basic
Basic
Earnings Per Share, Basic, Total
Cash Equivalents, at Carrying Value
Cash equivalents
Cash Equivalents, at Carrying Value, Total
Income Statement [Abstract]
Aptevo BioTherapeutics
Aptevo BioTherapeutics [Member]
Aptevo BioTherapeutics [Member]
Aptevo BioTherapeutics.
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment, Net
Lessee finance lease remaining term of contract.
Lessee Finance Lease Remaining Term Of Contract
Financing lease remaining term
Increase (Decrease) in Accounts Payable and Accrued Liabilities
Accounts payable, accrued compensation and other liabilities
Increase (Decrease) in Accounts Payable and Accrued Liabilities, Total
Selling, General and Administrative Expenses, Policy [Policy Text Block]
General and Administrative Expenses
Warrant modification - incremental fair value
Warrant modification - incremental value
Adjustments to Additional Paid in Capital, Warrant Issued
Operating Lease, Cost
Operating lease cost
Derivative, Cap Interest Rate
Cap interest rate
Retirement Benefits [Abstract]
Accounting Standards Update 2017-05 [Member]
ASC 610-20
Statistical Measurement [Domain]
Statistical Measurement
Net Cash Provided by (Used in) Operating Activities
Net cash used in operating activities
Net cash used in operating activities
Closing payments
Closing payments received
Closing payments received.
Shares released from abeyance
Number Of Shares Released From Abeyance
Number of shares released from abeyance.
All Award Types
Award Type
Document Period End Date
Document Period End Date
Change In R O U Asset And Lease Liability From Lease Remeasurement
Change in ROU asset and lease liability from lease remeasurement.
Change in right-of-use asset and lease liability from lease remeasurement
Statistical Measurement [Axis]
Statistical Measurement
Operating Lease, Payments
For operating leases
Earnings Per Share, Diluted
Diluted
Earnings Per Share, Diluted, Total
Income (Loss) from Discontinued Operations, Net of Tax, Including Portion Attributable to Noncontrolling Interest [Abstract]
Discontinued operations:
Deferred Tax Assets, Operating Loss Carryforwards, Domestic
Federal losses carryforward
Unrecognized Tax Benefits
Uncertain income tax positions
Unrecognized Tax Benefits, Beginning Balance
Unrecognized Tax Benefits, Ending Balance
Deferred Tax Assets, Operating Loss Carryforwards, State and Local
State losses carryforward
Debt Instrument, Name [Domain]
Debt Instrument, Name
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
Expiration amount of operating loss carryforwards
Expiration Amount Of Operating Loss Carryforwards
Amount of operating loss due to expire
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Number of Shares, Exercisable
Stock issued during period shares restricted stock award net of forfeitures and stock options exercised.
Stock Issued During Period Shares Restricted Stock Award Net of Forfeitures and Stock Options Exercised
Common stock issued upon vesting of restricted stock units and exercised stock options (in shares)
Gross proceeds
Proceeds Of Warrants Issued During Period Gross
Proceeds of warrants issued during period gross.
Related Party Transaction [Domain]
Related Party Transaction
Equity distribution agreement.
Equity Distribution Agreement [Member]
Equity Distribution Agreement
Payment interest purchase agreement.
Payment Interest Purchase Agreement [Member]
Payment Interest Purchase Agreement
Risk-free interest rate
Class Of Warrant Or Right Risk Free Interest Rate
Class of warrant or right risk free interest rate.
Proceeds from milestones related to sale of royalties
Proceeds From Milestones Related To Sale Of Royalties
Proceeds from milestones related to sale of royalties.
Summary of right of use assets acquired under operating leases.
Summary Of Right Of Use Assets Acquired Under Operating Leases Table [Text Block]
Summary of Right of Use Assets Acquired Under Operating Leases
Additional Paid in Capital, Common Stock
Additional paid-in capital
Defined Contribution Plan Disclosure [Line Items]
Defined Contribution Plan Disclosure [Line Items]
Revenue from Contract with Customer, Product and Service [Extensible Enumeration]
Revenue from Contract with Customer, Product and Service [Extensible List]
Proceeds from exercise of warrants value.
Proceeds From Exercise Of Warrants Value
Proceeds from exercise of warrants
Payment of royalty revenue
Payment of royalty revenue, percentage
Payment Of Royalty Revenue Percentage
Payment of royalty revenue, percentage.
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Common stock issued upon exercise of stock options
Number of Shares, Exercised
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Other
Liabilities and Equity [Abstract]
LIABILITIES AND STOCKHOLDERS' EQUITY
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Series A Common Warrants
Series A Common Warrant [Member]
Series A common warrant.
Liability related to sale of future royalties.
Liability Related To Sale Of Future Royalties
Liability related to sale of future royalties, beginning balance
Liability related to sale of royalties, ending balance
Entity Interactive Data Current
Entity Interactive Data Current
Defined Contribution Plan, Employer Matching Contribution, Percent of Match
Employer matching contribution, qualified deferral percentage
Aggregate offering price.
Aggregate Offering Price
Aggregate offering price
Credit Facility [Domain]
Credit Facility
Reduction in research and development expense.
Reduction In Research And Development Expense
Research and development expense
Equity [Abstract]
Weighted-Average Exercise Price, Outstanding, Ending Balance
Weighted-Average Exercise Price, Outstanding, Beginning Balance
Class Of Warrant Or Right Outstanding Weighted Average Exercise Price
Class of warrant or right outstanding weighted average exercise price.
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: imputed interest
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Number of Units, Granted
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Operating lease termination option written notice period.
Operating Lease Termination Option Written Notice Period
Operating lease termination option written notice period
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted-Average Exercise Price, Exercised
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash Equivalents
Basic and diluted net (loss) income per share from continuing operations:
Earnings Per Share, Basic [Abstract]
Equity Components [Axis]
Equity Components
Retirement Benefits [Text Block]
401(K) Savings Plan
Property and equipment
Deferred Tax Assets, Property, Plant and Equipment
Proceeds from warrant inducement, net of issuance cost
Proceeds from Issuance of Warrants
Share based compensation arrangement by share based payment award options granted intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Options Granted Intrinsic Value
Aggregate Intrinsic Value, Granted
Series A Junior Participating Preferred Stock.
Series A Junior Participating Preferred Stock [Member]
Series A Junior Participating Preferred Stock [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Weighted Average Fair Value per Unit, Vested
Local Phone Number
Local Phone Number
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Sale of Stock [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted-Average Exercise Price, Exercisable
Defined Contribution Plan [Table]
Defined Contribution Plan [Table]
Restricted Cash, Current
Restricted cash
Current restricted cash
Statement of Cash Flows [Abstract]
Earliest Tax Year [Member]
Earliest Tax Year
Transaction costs from sale of royalties
Transaction Costs From Sale Of Royalties
Transaction costs from sale of royalties.
Income Tax Authority [Domain]
Income Tax Authority
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment
Number of warrants issued.
Number Of Warrants Issued
Number of warrants issued
Document Annual Report
Document Annual Report
Accounts Payable and Other Accrued Liabilities, Current
Accounts payable and other accrued liabilities
Common stock par value
Common Stock, Par or Stated Value Per Share
Common stock, par value
Lessee operating lease unamortized real estate taxes interest rate.
Lessee Operating Lease Unamortized Real Estate Taxes Interest Rate
Operating lease termination option unamortized real estate taxes interest rate
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Term, Vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Stock authorized for issuance under Stock Plan
Discontinued Operation, Income (Loss) from Discontinued Operation, before Income Tax
Income from discontinued operations
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Collaborative Arrangement Disclosure [Text Block]
Collaboration Agreements
Maximum [Member]
Maximum
Maximum
Minimum percentage of common stock outstanding
Minimum Percentage of Common Stock Outstanding
Minimum percentage of common stock outstanding.
Sale of royalties liability disclosure abstract.
Sale Of Royalties Liability Disclosure [Abstract]
Earnings Per Share, Diluted [Abstract]
Diluted net income (loss) per share from continuing operations:
Related Party Transaction [Axis]
Related Party Transaction
Liability related to sale of future royalties non current.
Liability Related To Sale Of Future Royalties Non Current
Liability related to sale of royalties, non-current
Proceeds from sale of investments
Proceeds from Sale of Investments.
Proceeds From Sale Of Investments
Fair Value, Inputs, Level 3 [Member]
Level Three
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Basic Share [Abstract]
Basic net income per share from discontinued operations:
(Decrease) in cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Pre funded warrants and rights outstanding term.
Pre Funded Warrants And Rights Outstanding Term
Pre funded warrants outstanding, term
General and Administrative Expense [Member]
General and Administrative
Non-employee directors.
Non Employee Directors [Member]
Non-employee Directors
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Number of share options forfeited
Number of Shares, Forfeited
Number of Shares, Forfeited
Document Financial Statement Error Correction [Flag]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Summary of Potentially Dilutive Shares Excluded from Calculation of Net Loss Per Share
Payments for Royalties
RUXIENCE royalties paid by Pfizer to HCR
One time payment of royalties
Long-Term Debt, Maturities, Repayments of Principal in Next Rolling 12 Months
2023
City Area Code
City Area Code
Net Cash Provided by (Used in) Operating Activities [Abstract]
Operating Activities
Non-cash warrant modification costs
Non Cash Warrant Modification Costs
Non cash warrant modification costs.
Two thousand eighteen stock incentive plan.
Two Thousand Eighteen Stock Incentive Plan [Member]
2018 Stock Incentive Plan
Repayments under liability related to sale of royalties
Repayments Under Liability Related To Sale Of Royalties
Repayments under liability related to sale of royalties.
Letter of Credit [Member]
Letter of Credit
Operating lease property number of copiers.
Operating Lease Property Number Of Copiers
Operating lease number of copiers
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less: Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
Weighted Average Number of Shares Outstanding, Basic
Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Liability related to sale of royalties disclosure.
Liability Related To Sale Of Royalties Disclosure [Text Block]
Liability Related to Sale of Royalties
Number of shares held in abeyance and reserved for issuance
Number of shares held in abeyance and reserved for issuance.
Net Cash Provided by (Used in) Financing Activities [Abstract]
Financing Activities
Research and Development Expense, Policy [Policy Text Block]
Research and Development expense
HCR
HCR [member].
H C R [Member]
Milestone payment
Milestone payments.
Milestone Payment
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Summary of RSU Activity
Gain (Loss) on Extinguishment of Debt
Gain (Loss) on Extinguishment of Debt, Total
Loss on extinguishment of debt
Gain on extinguishment of liability related to sale of royalties
Statement [Table]
Statement [Table]
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
Schedule of Related Party Transactions, by Related Party [Table]
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Assumptions used in Valuing the Stock Options Granted under Black-Scholes Valuation Model
Document Fiscal Period Focus
Document Fiscal Period Focus
Lessee, Operating Lease, Liability, to be Paid
Total future minimum lease payments
XOMA Transaction
Related Party Transactions Disclosure [Text Block]
2025
Lessee, Operating Lease, Liability, to be Paid, Year Two
Statement [Line Items]
Statement [Line Items]
Nasdaq Capital Market.
Nasdaq Capital Market [Member]
Nasdaq Capital Market
Share based compensation arrangement by share based payment award options forfeitures in period intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period Intrinsic Value
Aggregate Intrinsic Value, Forfeited
Sharebased compensation arrangement by sharebased payment award options expected to vest weighted average period.
Sharebased Compensation Arrangement By Sharebased Payment Award Options Expected To Vest Weighted Average Period
Options expected to vest, weighted average period
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Anti-dilutive shares excluded from calculation of diluted net loss per share
Machinery and Equipment [Member]
Copier Leases
Lease, Cost
Total lease cost
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Warrant [Member]
Warrants
LIBOR [Member]
LIBOR.
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Tax Effects of Temporary Differences Give Rise to Significant Portions of Deferred Tax Assets and Deferred Tax Liabilities
Purchase agreement.
Purchase Agreement [Member]
Purchase Agreement
Common Stock [Member]
Common Stock
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Warrants expiration date
Warrants and Rights Outstanding, Maturity Date
Lessee operating lease unamortized tenant improvement allowance interest rate.
Lessee Operating Lease Unamortized Tenant Improvement Allowance Interest Rate
Operating lease termination option unamortized tenant improvement allowance interest rate
Series B-1 Common Warrants
Series B One Common Warrants [Member]
Series b one common warrants.
Total cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Stock-based Compensation Expense Includes Amortization of Stock Options and Restricted Stock Units Granted
Other Assets, Current
Other current assets
Aggregate intrinsic value of options exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate Intrinsic Value, Exercisable
Prepaid Expense, Current
Prepaid expenses
Prepaid Expense, Current, Total
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Weighted-Average Remaining Term, Outstanding
Class Of Warrant Or Right Outstanding Weighted Average Remaining Contractual Term
Class of warrant or right outstanding weighted average remaining contractual term.
Liability [Member]
Liability
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Income (Loss) from Continuing Operations before Income Taxes, Domestic
US
Long-Term Debt, Maturities, Repayments of Principal in Rolling Year Two
2024
Non cash interest expense.
Non Cash Interest Expense
Non-cash interest expense
Discontinued Operations and Disposal Groups [Abstract]
Cover [Abstract]
Vesting [Axis]
Vesting
Document Fiscal Year Focus
Document Fiscal Year Focus
Initial operating lease term date.
Initial Operating Lease Term Date
Initial operating lease term date
Sale of Stock [Domain]
Share-Based Payment Arrangement [Policy Text Block]
Stock-Based Compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted Average Fair Value per Unit, Granted
Lease liabilities
Deferred tax assets lease liabilities.
Deferred Tax Assets Lease Liabilities
Security Exchange Name
Security Exchange Name
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Stock plan termination period
Domestic Tax Authority [Member]
Federal
Milestone payment received net of transaction costs.
Milestone Payment Received Net Of Transaction Costs
Proceeds from milestone payments, net of transaction costs
Schedule of Cash and Cash Equivalents
Schedule of Cash and Cash Equivalents [Table Text Block]
New Accounting Pronouncements, Policy [Policy Text Block]
Recent Accounting Pronouncements
Preferred Stock, Shares Issued
Preferred stock, shares issued
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Additional post-closing payment.
Additional post-closing payment
Additional post-closing payment
Property, Plant and Equipment, Gross
Property and equipment, gross
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Number of Shares, Exercisable
Class Of Warrant Or Right Exercisable
Class of warrant or right exercisable
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Total operating leases
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted-Average Exercise Price, Forfeited
Business Acquisition, Acquiree [Domain]
Business Acquisition, Acquiree
Legal Entity [Axis]
Legal Entity
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Shares used in calculation:
Warrants and Rights Outstanding, Term
Warrants outstanding, term
Non-cash interest expense and other.
Non Cash Interest Expense And Other
Non-cash interest expense and other
Entity Emerging Growth Company
Entity Emerging Growth Company
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Aggregate Intrinsic Value, Exercised
Restricted Cash and Cash Equivalents Items [Line Items]
Restricted Cash And Cash Equivalents Items [Line Items]
Hyperimmune business.
Hyperimmune Business [Member]
Hyperimmune Business
Amendment Flag
Amendment Flag
Tax Credit Carryforward, Amount
Tax credit carryforwards
Finance lease number of equipment.
Finance Lease Number Of Equipment
Financing lease number of equipment
Banker and legal fees
Banker And Legal Fees
Banker and legal fees.
Series B-2 Common Warrants
Series B Two Common Warrants [Member]
Series b two common warrants.
New Warrants
New Warrants [Member]
New warrants.
Public Offering
IPO [Member]
Additional milestone payment.
Additional Milestone Payment
Additional milestone payment
Accounting Standards Update [Domain]
Number of operating lease renewal options.
Number Of Operating Lease Renewal Options
Number of operating lease renewal option
Leases [Abstract]
Variable Rate [Domain]
Variable Rate
Tax Period [Domain]
Tax Period
Assumptions used in Estimating the Incremental Fair Value of the Exchanged Common Warrants under Black-scholes Valuation Model
Assumptions Of Incremental Fair Value Of Warrants [Table Text Block]
Assumptions of incremental fair value of warrants.
Securities Act File Number
Entity File Number
Deferred Tax Assets, Gross
Deferred tax assets, gross
Weighted-Average Exercise Price, Exercised
Class Of Warrant Or Right Exercised Weighted Average Exercise Price
Class of warrant or right exercised weighted average exercise price.
Warrants exercisable date
Class of Warrant or Right, Date from which Warrants or Rights Exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Aggregate Intrinsic Value, Vested and expected to vest
Long-Term Debt, Excluding Current Maturities
Long-term debt
Long-Term Debt, Excluding Current Maturities, Total
Income (Loss) from Discontinued Operations, Net of Tax, Including Portion Attributable to Noncontrolling Interest
Income from discontinued operations
Income from discontinued operations
Disposal Group Classification [Domain]
Disposal Group Classification
Debt Instrument [Axis]
Debt Instrument
Schedule of earnings per share basic and diluted.
Schedule Of Earnings Per Share Basic And Diluted [Line Items]
Schedule Of Earnings Per Share Basic And Diluted [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Weighted Average Fair Value per Unit, Outstanding Ending Balance
Weighted Average Fair Value per Unit, Outstanding Beginning Balance
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Proceeds from sale of investments used.
Proceeds From Sale Of Investments Used
Proceeds from sale of investments used
Auditor Location
Auditor Location
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected average life of options
Share portion entitled to purchase by rights.
Share Portion Entitled To Purchase By Rights1
Share portion entitled to purchase by rights
Entity Address, Address Line Two
Entity Address, Address Line Two
Deferred Tax Assets, Goodwill and Intangible Assets
Intangible assets
Preferred Stock, Value, Issued
Preferred stock: $0.001 par value; 15,000,000 shares authorized, zero shares issued or outstanding
Entity Small Business
Entity Small Business
Entity Shell Company
Entity Shell Company
Title of Individual [Axis]
Title of Individual
Class of Warrant or Right, Exercise Price of Warrants or Rights
Warrants exercise price, per share
Class of Warrant or Right [Domain]
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized compensation expense
Business Exit Costs
Exit fees
Nature Of Business [Line Items]
Nature Of Business [Line Items]
Nature Of Business [Line Items]
Earnings Per Share [Text Block]
Net Income (Loss) per Share
Share based compensation arrangement by share based payment award options expected to vest weighted average remaining vesting period.
Share Based Compensation Arrangement By Share Based Payment Award Options Expected To Vest Weighted Average Remaining Vesting Period
Options expected to vest, weighted average remaining vesting term
Entity Address, Address Line One
Entity Address, Address Line One
Antidilutive Securities [Axis]
Antidilutive Securities
Other Liabilities, Current
Other current liabilities
Tabular disclosure of future minimum payments required for operating leases.
Schedule Of Future Minimum Payments For Operating Leases Table [Text Block]
Summary of Future Minimum Lease Payments
Subsequent Event Type [Domain]
Subsequent Event Type
Income Statement Location [Axis]
Income Statement Location
Gain from extinguishment of liability related to sale of royalties
Gain on extinguishment of liability related to sale of royalties.
Gain On Extinguishment Of Liability Related To Sale Of Royalties
Gain on extinguishment of liability related to sale of royalties
Gain from extinguishment of liability related to sale of royalties
Variable Lease, Cost
Variable expense
Schedule of changes in the liability related to the sale of royalties.
Schedule Of Changes In Liability Related To Sale Of Royalties Table [Text Block]
Schedule of Changes in the Liability Related to the Sale of Royalties
Expected volatility
Class Of Warrant Or Right Expected Volatility Rate
Class of warrant or right expected volatility rate.
Summary of Warrant Activity
Warrant Activity [Table Text Block]
Warrant activity.
Tang [member].
Tang [Member]
Tang
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Series B Common Warrants
Series B Common Warrants [Member]
Series B Common Warrants.
Net (loss) income
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Value of equity awards withheld for tax liability
Value Of Equity Awards Withheld For Tax Liability
Value of equity awards withheld for tax liability.
Number of technology platforms.
Number Of Technology Platforms
Number of technology platforms
Fair Value, Inputs, Level 2 [Member]
Level Two
Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Basic Share
Basic
Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Basic Share, Total
Share Price
Minimum prevailing market price to direct purchase
Depreciation, Depletion and Amortization
Depreciation and amortization
Depreciation, Depletion and Amortization, Total
RUXIENCE
R U X I E N C E [Member]
R U X I E N C E
Title of 12(b) Security
Title of 12(b) Security
Percentage of entitlement to receive European approval milestone payment
Percentage of entitlement to receive European approval milestone payment
Percentage of entitlement to receive European approval milestone payment.
Percentage Of Beneficial Ownership.
Percentage Of Beneficial Ownership
Percentage of beneficial ownership
Number of Shares, Exercised
Class Of Warrant Or Right Exercised
Class of warrant or right exercised.
Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Diluted Share
Diluted
Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Diluted Share, Total
Money Market Funds, at Carrying Value
Money market funds
Schedule of Financing Receivables, Minimum Payments [Table Text Block]
Schedule of Future Principal, Interest, and Other Related Fee Payments in Connection with the Credit Agreement
Accounting Standards Update [Axis]
Other Nonoperating Income (Expense) [Abstract]
Other income (expense):
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Permanent differences
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
Weighted-Average Remaining Term, Exercised with shares held in abeyance
Class Of Warrant Or Right Exercised With Shares Held In Abeyance Weighted Average Remaining Contractual Term
Class of warrant or right exercised with shares held in abeyance weighted average remaining contractual term.
Leaseholds and Leasehold Improvements [Member]
Leasehold Improvements
Net Cash Provided by (Used in) Investing Activities [Abstract]
Investing Activities
State and Local Jurisdiction [Member]
State
Segment Reporting, Policy [Policy Text Block]
Segment Reporting
Seattle office lease including amendment.
Seattle Office Lease Including Amendment [Member]
Seattle Office Lease, Including Amendment
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Subsequent Event [Table]
Subsequent Event [Table]
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Restricted Cash
Income taxes.
Income Taxes [Line Items]
Income Taxes [Line Items]
Shares remained abeyance
Number Of Shares Remained Abeyance
Number of shares remained abeyance.
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Term, Exercisable
Pre funded warrants exercise price.
Pre Funded Warrants Exercise Price
Pre funded warrants exercise price, per share
Common stock outstanding
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Weighted Average Fair Value per Unit, Forfeited
Proceeds from Warrant Exercises
Proceeds from exercises of warrants
Liability related to sale of royalties and other income (expense).
Liability Related To Sale Of Royalties And Other Income (Expense) Policy [Text Block]
Liability Related to Sale of Royalties and Other Income (Expense)
Lessee, Operating Lease, Discount Rate
Operating lease discounted incremental borrowing rate
Income Statement Location [Domain]
Income Statement Location
Mid Cap financial [Member]
Mid Cap Financial [Member]
Mid Cap Financial
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted-Average Exercise Price, Granted
Document Type
Document Type
Operating leases, excluding Seattle office lease.
Operating Leases Excluding Seattle Office Lease [Member]
Operating Leases, Excluding Seattle Office Lease
Line of Credit Facility, Current Borrowing Capacity
Line of credit facility, used borrowing capacity
Fair Value by Liability Class [Domain]
Fair Value by Liability Class
Net Cash Provided by (Used in) Investing Activities
Net cash used in investing activities
Deferred Tax Assets, Tax Credit Carryforwards, Other
Other tax credits
Counterparty Name [Domain]
Counterparty Name
Disposal Group Classification [Axis]
Disposal Group Classification
Share based compensation arrangement by share based payment award fair value assumptions expected volatility share price.
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Share Price
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Number of Units, Forfeited
Net cash provided by (used in) financing activities
Net Cash Provided by (Used in) Financing Activities
Total issuance costs
Issuance of costs
Warrants Issuance Costs
Warrants issuance costs.
Entity Filer Category
Entity Filer Category
Operating loss carryforwards, expiration year.
Operating Loss Carryforwards Expiration Year
Operating losses, begin to expiration year
Nature Of Business [Table]
Nature Of Business [Table]
Nature Of Business [Table]
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Schedule of Income (Loss) from Continuing Operations Before Income Taxes
Variable Rate [Axis]
Variable Rate
Percentage of number of common stock issued upon exercise of warrants
Percentage of Number of Common Stock Issued Upon Exercise of Warrants
Percentage of number of common stock issued upon exercise of warrants.
Prefunded warrant expiration date.
Prefunded Warrant Expiration Date
Pre funded warrants expire date
Pre-funded Warrants
Pre-funded Warrants [Member]
Pre-funded Warrants.
Liabilities
Total liabilities
Income taxes.
Income Taxes [Table]
Income Taxes [Table]
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
ROU assets
Deferred tax liability right of use assets.
Deferred Tax Liability Right Of Use Assets
Series A-1 Common Warrants
Series A One Common Warrants [Member]
Series a one common warrants.
Equity, Attributable to Parent
Balance
Balance
Total stockholders' equity
Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate [Member]
Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate
SOFR
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Net income (loss) for the period
Net income (loss)
Net (loss) income
Net Income (Loss)
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State taxes, net of federal benefit
Fair Value Measurement, Policy [Policy Text Block]
Fair Value of Financial Instruments
Statement of Financial Position [Abstract]
Basis of Presentation and Significant Accounting Policies [Text Block]
Basis of Presentation
Weighted Average Number of Shares Outstanding, Diluted
Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Liability related to sale of future royalties current.
Liability Related To Sale Of Future Royalties Current
Current portion of liability related to sale of royalties
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Reconciliation of Federal Statutory Income Tax Rate to Effective Income Tax from Continuing Operations
Credit Facility [Axis]
Credit Facility
Common stock price per share
Shares Issued, Price Per Share
Average share price
Effective Income Tax Rate Reconciliation, Percent
Total income tax benefit
Income (Loss) from Continuing Operations, Per Basic Share
Basic
Operating Lease, Weighted Average Remaining Lease Term
Weighted average remaining lease term for operating leases
Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent
Maximum employee deferral rate
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Income Tax Disclosure [Text Block]
Income Taxes
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Income Statement Balance Sheet And Additional Disclosures By Disposal Groups Including Discontinued Operations [Line Items]
Restricted stock units and options.
Restricted Stock Units And Options [Member]
RSUs and Options
Stock issued during period value restricted stock award net of forfeitures and stock options exercised.
Stock Issued During Period Value Restricted Stock Award Net of Forfeitures and Stock Options Exercised
Common stock issued upon vesting of restricted stock units and exercised stock options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted-Average Exercise Price, Outstanding, Ending balance
Weighted-Average Exercise Price, Outstanding, Beginning balance
Derivative, Floor Interest Rate
Floor interest rate
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Computation of Basic and Diluted Net Income (Loss) per Share
Number of warrants to be expired
Class Of Warrant Or Right To Be Expired
Class of warrant or right to be expired.
Income Tax Authority [Axis]
Income Tax Authority
Fair Value Disclosures [Abstract]
Current Income Tax Expense (Benefit)
Income tax expense (benefit)
Current Income Tax Expense (Benefit), Total
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Finance Lease, Interest Expense
Interest on lease liabilities
Financing lease remaining expense obligation
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Number of Units, Vested
Commitment shares issued/ proceeds from issuance of common stock (in shares)
Stock Issued During Period, Shares, New Issues
Issuance of common stock shares
Employee-related Liabilities, Current
Accrued compensation
Employee-related Liabilities, Current, Total
Business Acquisition [Axis]
Business Acquisition
Cash and cash equivalents at end of period
Cash and cash equivalents at beginning of period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Royalty revenue
Revenues From Net Sales
Revenues from net sales.
Class of Warrant or Right [Axis]
Income Tax Disclosure [Abstract]
Operating Loss Carryforwards
Net operating loss carryforwards