Aptevo Therapeutics Files Provisional Patent for Fifth Bispecific Antibody APVO711, Intended for the Treatment of Solid Tumors
New PD-L1 x CD40 Candidate Built on Proprietary ADAPTIR™ Platform, Enters Pre-Clinical Pipeline
"Identifying new approaches to address the unmet needs of cancer patients is critical and APVO711 represents just such a new approach. This bispecific molecule targeting PD-L1 and CD40 is designed to function with new mechanisms of action and to synergistically induce a biological response. This is achieved by simultaneously engaging in two validated T cell activating mechanisms: 1) by blocking of PD-L1/PD-1 inhibitory pathway and 2) by enhancing T cell priming through activation of the stimulatory receptor CD40 on antigen presenting cells. APVO711 is designed to activate CD40 only in the presence of PD-L1 for an ideal safety profile." said
"We are very pleased to announce that APVO711 is entering pre-clinical studies. This new compound expands our anti-cancer portfolio to five molecules and provides potential for another novel pathway to more effective cancer therapies in solid tumors," said
Safe Harbor Statement
This press release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical fact, including, without limitation, Aptevo's expectations about the activity, efficacy and safety of its therapeutic candidates as monotherapies or combination therapies and potential use of any such candidates as therapeutics for treatment of disease, its expectations regarding the effectiveness of its ADAPTIR and ADAPTIR-FLEX platforms, whether pre-clinical studies of APVO711 will show the desired anti-tumor efficacy, mechanism of action and safety profile and whether APVO711 will function with new mechanisms of action compared to our previous candidates and synergistically induce a biological response, whether APVO711 will demonstrate the ability to fight a range of solid malignancies, whether Aptevo's provisional patent application will result in a patent or adequately protect APVO711, the anticipated time of the initiation of APVO711 pre-clinical studies, statements relating to the progress of Aptevo's clinical programs, especially APVO436, and any other statements containing the words "may," "anticipate," "continue to," "believes," "expects," "intended to," "potential," "designed," "plans," "will" and similar expressions are intended to identify forward-looking statements. These forward-looking statements are based on Aptevo's current intentions, beliefs, and expectations regarding future events. Aptevo cannot guarantee that any forward-looking statement will be accurate. Investors should realize that if underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could differ materially from Aptevo's expectations. Investors are, therefore, cautioned not to place undue reliance on any forward-looking statement.
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