Aptevo Therapeutics Announces Second Complete Remission in Ongoing APVO436 Phase 1 Clinical Trial
Second Complete Remission Observed in a Patient in Cohort 6
Enrollment in Cohort 8 Has Started
Seattle, WA / ACCESSWIRE /
APVO436 is a novel anti-CD123 x anti-CD3 targeted investigational bispecific antibody therapy being evaluated for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), in a Phase 1/1b open-label, dose-escalation study evaluating the safety and pharmacokinetic profile.
Details related to the second patient with complete remission are as follows:
- Patient bone marrow blasts were 33% at screen, exhibited a rise in blasts to 46% after the first cycle of treatment. Subsequently, the bone marrow blasts dropped to 8% after the second cycle, and to 4% after the fourth cycle of treatment.
- The patient's platelet count and absolute neutrophil count (ANC) met complete remission criteria (CR).
"It is very encouraging that two complete remissions have been observed in Cohort 6, as we are now enrolling in cohort 8," said
APVO436 was built on Aptevo's next generation proprietary ADAPTIR™ protein therapeutic platform. Focused on generating novel, targeted bispecific antibody-based immunotherapies for cancer the ADAPTIR™ platform offers key advantages over other bispecific formats, derived in part from the flexible and modular nature of the ADAPTIR™ structure.
Aptevo believes that its differentiated ADAPTIR™ bispecific technology platform has the potential to offer a more convenient and cost-effective solution compared to other immunotherapies such as CAR-T therapies. While CAR-T therapies have proven effective in generating robust and durable treatment responses, they remain challenging and expensive to manufacture and administer to patients. In contrast, bispecific technologies may represent a simpler, more competitive ‘off-the-shelf' solution in the rapidly advancing field of cancer immunotherapy.
Aptevo will be presenting a poster at the 62nd Annual
The ASH conference has already posted an abstract on APVO436 titled: "Preliminary Results from a Phase 1 Study of APVO436, a Novel Anti-CD123 x Anti-CD3 Bispecific Molecule, in Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome" publicly available on the conference site, which provides details on the clinical trial : https://ash.confex.com/ash/2020/webprogram/Paper141619.html.
Aptevo will continue to provide updates on its ongoing APVO436 Phase 1 Clinical Trial as and when appropriate.
Aptevo defines complete remission (CR), stable disease, and progressive disease in a manner consistent with the European LeukemiaNet (ELN) 2017 criteria, reference: Döhner H, Estey E, Grimwade D, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017; 129(4): 424-447.
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